FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046923162> ?p ?o ?g. }

• W2046923162 endingPage "84" @default.
• W2046923162 startingPage "74" @default.
• W2046923162 abstract "A poorly controlled acute inflammatory response can lead to organ dysfunction and death. Severe systemic inflammation can be induced and perpetuated by diverse insults such as the administration of toxic bacterial products (e.g., endotoxin), traumatic injury, and hemorrhage. Here, we probe whether these varied shock states can be explained by a universal inflammatory system that is initiated through different means and, once initiated, follows a course specified by the cellular and molecular mechanisms of the immune and endocrine systems. To examine this question, we developed a mathematical model incorporating major elements of the acute inflammatory response in C57Bl/6 mice, using input from experimental data. We found that a single model with different initiators including the autonomic system could describe the response to various insults. This model was able to predict a dose range of endotoxin at which mice would die despite having been calibrated only in nonlethal inflammatory paradigms. These results show that the complex biology of inflammation can be modeled and supports the hypothesis that shock states induced by a range of physiologic challenges could arise from a universal response that is differently initiated and modulated." @default.
• W2046923162 created "2016-06-24" @default.
• W2046923162 creator A5004982710 @default.
• W2046923162 creator A5027696104 @default.
• W2046923162 creator A5034374861 @default.
• W2046923162 creator A5035668981 @default.
• W2046923162 creator A5039419259 @default.
• W2046923162 creator A5052569785 @default.
• W2046923162 creator A5053511755 @default.
• W2046923162 creator A5062076820 @default.
• W2046923162 creator A5073022985 @default.
• W2046923162 creator A5078247161 @default.
• W2046923162 creator A5078253661 @default.
• W2046923162 creator A5082272833 @default.
• W2046923162 date "2005-07-01" @default.
• W2046923162 modified "2023-10-02" @default.
• W2046923162 title "THE ACUTE INFLAMMATORY RESPONSE IN DIVERSE SHOCK STATES" @default.
• W2046923162 cites W12754177 @default.
• W2046923162 cites W1537812171 @default.
• W2046923162 cites W1560571961 @default.
• W2046923162 cites W1567207438 @default.
• W2046923162 cites W1570331116 @default.
• W2046923162 cites W1641228030 @default.
• W2046923162 cites W1893843169 @default.
• W2046923162 cites W1927790510 @default.
• W2046923162 cites W1931331902 @default.
• W2046923162 cites W1953009759 @default.
• W2046923162 cites W1969533119 @default.
• W2046923162 cites W1969986606 @default.
• W2046923162 cites W1970103447 @default.
• W2046923162 cites W1977056189 @default.
• W2046923162 cites W1977523316 @default.
• W2046923162 cites W1978486653 @default.
• W2046923162 cites W1980220254 @default.
• W2046923162 cites W1985264236 @default.
• W2046923162 cites W1992033406 @default.
• W2046923162 cites W1992113771 @default.
• W2046923162 cites W1995525413 @default.
• W2046923162 cites W1996752594 @default.
• W2046923162 cites W1997741202 @default.
• W2046923162 cites W2009550948 @default.
• W2046923162 cites W2010757739 @default.
• W2046923162 cites W2011128646 @default.
• W2046923162 cites W2017172862 @default.
• W2046923162 cites W2019161209 @default.
• W2046923162 cites W2023447635 @default.
• W2046923162 cites W2024133296 @default.
• W2046923162 cites W2029669740 @default.
• W2046923162 cites W2034083518 @default.
• W2046923162 cites W2040434135 @default.
• W2046923162 cites W2043384239 @default.
• W2046923162 cites W2047822772 @default.
• W2046923162 cites W2048142078 @default.
• W2046923162 cites W2048187276 @default.
• W2046923162 cites W2049927822 @default.
• W2046923162 cites W2049990564 @default.
• W2046923162 cites W2052562838 @default.
• W2046923162 cites W2053033670 @default.
• W2046923162 cites W2054247098 @default.
• W2046923162 cites W2056879548 @default.
• W2046923162 cites W2057018521 @default.
• W2046923162 cites W2057927549 @default.
• W2046923162 cites W2057979643 @default.
• W2046923162 cites W2060269445 @default.
• W2046923162 cites W2060422880 @default.
• W2046923162 cites W2060928705 @default.
• W2046923162 cites W2065838572 @default.
• W2046923162 cites W2067761476 @default.
• W2046923162 cites W2072284181 @default.
• W2046923162 cites W2073132923 @default.
• W2046923162 cites W2075758761 @default.
• W2046923162 cites W2076642686 @default.
• W2046923162 cites W2080354420 @default.
• W2046923162 cites W2083223483 @default.
• W2046923162 cites W2087823687 @default.
• W2046923162 cites W2088713567 @default.
• W2046923162 cites W2093058653 @default.
• W2046923162 cites W2112686176 @default.
• W2046923162 cites W2113769407 @default.
• W2046923162 cites W2120600063 @default.
• W2046923162 cites W2122647885 @default.
• W2046923162 cites W2123151246 @default.
• W2046923162 cites W2125103726 @default.
• W2046923162 cites W2125751904 @default.
• W2046923162 cites W2128494605 @default.
• W2046923162 cites W2133831451 @default.
• W2046923162 cites W2134033609 @default.
• W2046923162 cites W2138387587 @default.
• W2046923162 cites W2139152961 @default.
• W2046923162 cites W2139406166 @default.
• W2046923162 cites W2145736817 @default.
• W2046923162 cites W2151365647 @default.
• W2046923162 cites W2151673904 @default.
• W2046923162 cites W2154923159 @default.
• W2046923162 cites W2156661166 @default.
• W2046923162 cites W2157282632 @default.
• W2046923162 cites W2160232295 @default.
• W2046923162 cites W2161014233 @default.

• next