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- W2046932726 abstract "Abstract Transducing phage λdg differs from bacteriophage λ in the low frequency with which it integrates into and excises from the bacterial chromosome. Nevertheless, on infection or induction, λdg can produce the diffusible elements required for integrative recombination, since it complements and is complemented by the mutant λint6 . Cis-trans tests of the ability of various phages and prophages to complement the integration-excision defect of λdg have shown that such complementation can only occur in cis . These observations lead us to conclude that λdg lacks a structural element needed for normal integration and excision. We have accounted for this defect by assuming that the attachment region on the λ chromosome is not completely homologous to the bacterial attachment region. Thus, Int-promoted recombination between the phage and bacterial chromosomes at the attachment regions will result in a prophage which is bordered at its left- and right-hand termini by two new and structurally unique prophage attachment regions. The frequency of Int-promoted recombination between different attachment regions must depend on the structure of the pair involved, with recombination between λdg (which carries the left prophage attachment region) and the bacterial chromosome evidently being infrequent. Although the molecular basis of this dependence is unknown, we can show that the recombination frequency is not a simple function of the amount of homology shared by the two recombining structures." @default.
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- W2046932726 date "1969-12-01" @default.
- W2046932726 modified "2023-09-24" @default.
- W2046932726 title "The integration and excision defect of bacteriophage λdg" @default.
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- W2046932726 doi "https://doi.org/10.1016/0022-2836(69)90196-x" @default.
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