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- W2046938151 abstract "Taranabant (1) is a cannabinoid-1 receptor (CB1R) inverse agonist that was recently in late-stage clinical development for the treatment of obesity. The previously employed synthesis exhibited a number of shortcomings for continuing development, and in this paper we report an improved synthesis of the target molecule that is suitable for large-scale implementation. Palladium-catalyzed amidation of an enol tosylate afforded a stereodefined tetrasubstituted enamide, and asymmetric hydrogenation thereof provided the target molecule." @default.
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- W2046938151 date "2009-01-16" @default.
- W2046938151 modified "2023-09-26" @default.
- W2046938151 title "New Efficient Asymmetric Synthesis of Taranabant, a CB1R Inverse Agonist for the Treatment of Obesity" @default.
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- W2046938151 doi "https://doi.org/10.1021/op800270e" @default.
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