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- W204694149 abstract "CA1 pyramidal cells (PCs) provide a major output of the hippocampus proper. They integrate information arriving directly from the entorhinal cortex via the temporoammonic pathway, and indirectly via the polysynaptic dentate gyrus–CA3–CA1 loop. Both pathways terminate in a spatially segregated manner onto CA1 PC apical dendrites. The temporoammonic pathway targets the distal dendrites in the stratum lacunosum moleculare, while CA3 PC axons terminate within the stratum radiatum. These inputs are integrated in the somatodendritic compartment and converted to an output consisting of action potentials propagating along the CA1 axons, a process controlled by the intrinsic membrane properties of CA1 neurons. We will first consider the mechanisms determining input–output properties of normal CA1 PCs. We will then address how the properties of CA1 PCs change in acute and chronic epilepsy models, and how they might contribute to increased excitability." @default.
- W204694149 created "2016-06-24" @default.
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- W204694149 date "2009-01-01" @default.
- W204694149 modified "2023-09-24" @default.
- W204694149 title "PYRAMIDAL CELLS | Intrinsic Plasticity of Hippocampal CA1 Pyramidal Cells and its Relevance to Epileptic Discharge and Epileptogenesis" @default.
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- W204694149 doi "https://doi.org/10.1016/b978-012373961-2.00218-6" @default.
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