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• W2046959486 abstract "No AccessJournal of UrologyInvestigative Urology1 Mar 1998ROLE OF CHRONIC INFLAMMATION IN THE PROMOTION OF PROSTATIC HYPERPLASIA IN RATS ODED J. KESSLER, YONA KEISARI, CIRO SERVADIO, and ARMAND ABRAMOVICI ODED J. KESSLERODED J. KESSLER More articles by this author , YONA KEISARIYONA KEISARI More articles by this author , CIRO SERVADIOCIRO SERVADIO More articles by this author , and ARMAND ABRAMOVICIARMAND ABRAMOVICI More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63834-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Chronic prostatitis is a common histopathological finding in prostatectomized patients. A possible interrelationship between the presence of leukocyte exudate and the extent of the hyperplastic lesions has been suggested. The aim of the present study was to analyze the effect of the immunomodulator compounds, Complete Freund Adjuvant (CFA) and cyclosporin A (CsA), administered alone or together with citral on the induction and extent of rat prostatic hyperplasia. Materials and Methods: Adolescent Wistar rats (42 days old) were given citral alone or combined with CFA or CsA for one month. Semiquantitative analysis of the extent of the hyperplastic lesions was made with the histoscore protocol. Results: CsA did not induce hyperplastic changes or abolish the ability of citral to promote hyperplastic changes or to affect the extent of the lymphocytic exudate in the stroma. CFA itself, however, had a proliferative action on the prostatic epithelium, and it augmented the hyperplastic changes induced by citral and even induced atypical transformations of the acinar epithelium. Conclusions: Immunoinflammatory stimulators might play a role in the prostatic epithelial cell growth and proliferation processes, most probably by modulation of the cytokine system. References 1 : The development of human benign prostatic hyperplasia with age. J. Urol.1995; 132: 474. Google Scholar 2 : A comparison of human and canine benign prostatic hyperplasia. In: Regulation of Androgen Action.. Edited by . W. Germany: Congressbruck R. Bruckner1985: 59. Google Scholar 3 : Comparison of spontaneous and experimentally induced canine prostatic hyperplasia. J. Clin. Invest.1979; 64: 842. Google Scholar 4 Bosland, M. C.: Monographs and Pathology of Laboratory Animals: Genital System. Edited by T. C. Jones, V. Mohr and R. D. Hunt, pp. 252, Springer-Verlag: NY. Google Scholar 5 : Morphologic and regulatory aspects of prostatic function. Anat. Embryol.1989; 179: 519. Google Scholar 6 : Androgenic response in the prostate: the role of stromal epithelial interaction. 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Urol. Res.1992; 20: 130. Google Scholar 46 : Sex hormone induced inflammation and fibromuscular proliferation in the rat lateral prostate. Prostate1988; 12: 271. Google Scholar 47 : Allergic contact dermatitis resulting from sensitivity to citrus peel, geraniol and citral. J. Am. Acad. Dermatol.1989; 21: 395. Google Scholar From the Institute of Urology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, and the Departments of Human Microbiology and Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGerstenbluth R, Seftel A, MacLennan G, Rao R, Corty E, Ferguson K and Resnick M (2018) Distribution of Chronic Prostatitis in Radical Prostatectomy Specimens With Up-Regulation of BCL-2 in Areas of InflammationJournal of Urology, VOL. 167, NO. 5, (2267-2270), Online publication date: 1-May-2002. Volume 159Issue 3March 1998Page: 1049-1053 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information ODED J. KESSLER More articles by this author YONA KEISARI More articles by this author CIRO SERVADIO More articles by this author ARMAND ABRAMOVICI More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2046959486 title "ROLE OF CHRONIC INFLAMMATION IN THE PROMOTION OF PROSTATIC HYPERPLASIA IN RATS" @default.
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