Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046963100> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2046963100 endingPage "416" @default.
- W2046963100 startingPage "410" @default.
- W2046963100 abstract "Paclitaxel (Taxol), a microtubule stabilizer with antitumor activity, mimics certain effects of lipopolysaccharide (LPS) in murine macrophages. We examined the mechanism by which Taxol regulates the expression of inducible nitric oxide synthase (iNOS) in a murine macrophage cell line. Taxol alone induced iNOS mRNA and promoter activity, but no iNOS protein or NO production. The stability of the iNOS mRNA formed in response to Taxol was lower than that formed in response to IFN-γ or LPS, and this may have been responsible for the lack of induction of iNOS protein and NO. However, IFN-γ synergized with Taxol by increasing iNOS mRNA stability, and upregulating levels of iNOS mRNA and protein, promoter activity, and NO production. Transfection experiments with 5′-serial deletions and site-directed mutants of the iNOS promoter revealed that the pair of upstream and downstream NF-κB sites was crucial for promoter activity in response to Taxol, as in the case of LPS. Electrophoretic mobility shift assays showed that both Taxol and LPS rapidly activated identical NF-κB complexes that could bind to the iNOS promoter. These results suggest that Taxol shares a signaling pathway for transcriptional activation of iNOS with LPS, but that the stability of the iNOS mRNA induced by Taxol is different from that induced by LPS." @default.
- W2046963100 created "2016-06-24" @default.
- W2046963100 creator A5057122838 @default.
- W2046963100 creator A5087456386 @default.
- W2046963100 date "2005-01-01" @default.
- W2046963100 modified "2023-10-16" @default.
- W2046963100 title "Induction of expression of inducible nitric oxide synthase by Taxol in murine macrophage cells" @default.
- W2046963100 cites W1480509123 @default.
- W2046963100 cites W1496717884 @default.
- W2046963100 cites W1558017075 @default.
- W2046963100 cites W1591881963 @default.
- W2046963100 cites W1666870571 @default.
- W2046963100 cites W1853090825 @default.
- W2046963100 cites W1875764398 @default.
- W2046963100 cites W1903763536 @default.
- W2046963100 cites W1956304128 @default.
- W2046963100 cites W1973018387 @default.
- W2046963100 cites W1990802251 @default.
- W2046963100 cites W1993354784 @default.
- W2046963100 cites W1994303699 @default.
- W2046963100 cites W1994389040 @default.
- W2046963100 cites W1998276910 @default.
- W2046963100 cites W2001766586 @default.
- W2046963100 cites W2013510760 @default.
- W2046963100 cites W2019685266 @default.
- W2046963100 cites W2023170094 @default.
- W2046963100 cites W2029706883 @default.
- W2046963100 cites W2034409870 @default.
- W2046963100 cites W2050283646 @default.
- W2046963100 cites W2072668724 @default.
- W2046963100 cites W2073132923 @default.
- W2046963100 cites W2113580903 @default.
- W2046963100 cites W2119092109 @default.
- W2046963100 cites W2144206181 @default.
- W2046963100 cites W2151892297 @default.
- W2046963100 cites W2154335454 @default.
- W2046963100 cites W2157786727 @default.
- W2046963100 cites W2436860975 @default.
- W2046963100 cites W4255762755 @default.
- W2046963100 doi "https://doi.org/10.1016/j.bbrc.2004.11.043" @default.
- W2046963100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15582593" @default.
- W2046963100 hasPublicationYear "2005" @default.
- W2046963100 type Work @default.
- W2046963100 sameAs 2046963100 @default.
- W2046963100 citedByCount "17" @default.
- W2046963100 countsByYear W20469631002012 @default.
- W2046963100 countsByYear W20469631002018 @default.
- W2046963100 crossrefType "journal-article" @default.
- W2046963100 hasAuthorship W2046963100A5057122838 @default.
- W2046963100 hasAuthorship W2046963100A5087456386 @default.
- W2046963100 hasConcept C104317684 @default.
- W2046963100 hasConcept C105580179 @default.
- W2046963100 hasConcept C153911025 @default.
- W2046963100 hasConcept C178790620 @default.
- W2046963100 hasConcept C185592680 @default.
- W2046963100 hasConcept C203014093 @default.
- W2046963100 hasConcept C2777622882 @default.
- W2046963100 hasConcept C2778754761 @default.
- W2046963100 hasConcept C519581460 @default.
- W2046963100 hasConcept C54009773 @default.
- W2046963100 hasConcept C55493867 @default.
- W2046963100 hasConcept C86803240 @default.
- W2046963100 hasConcept C95444343 @default.
- W2046963100 hasConceptScore W2046963100C104317684 @default.
- W2046963100 hasConceptScore W2046963100C105580179 @default.
- W2046963100 hasConceptScore W2046963100C153911025 @default.
- W2046963100 hasConceptScore W2046963100C178790620 @default.
- W2046963100 hasConceptScore W2046963100C185592680 @default.
- W2046963100 hasConceptScore W2046963100C203014093 @default.
- W2046963100 hasConceptScore W2046963100C2777622882 @default.
- W2046963100 hasConceptScore W2046963100C2778754761 @default.
- W2046963100 hasConceptScore W2046963100C519581460 @default.
- W2046963100 hasConceptScore W2046963100C54009773 @default.
- W2046963100 hasConceptScore W2046963100C55493867 @default.
- W2046963100 hasConceptScore W2046963100C86803240 @default.
- W2046963100 hasConceptScore W2046963100C95444343 @default.
- W2046963100 hasIssue "2" @default.
- W2046963100 hasLocation W20469631001 @default.
- W2046963100 hasLocation W20469631002 @default.
- W2046963100 hasOpenAccess W2046963100 @default.
- W2046963100 hasPrimaryLocation W20469631001 @default.
- W2046963100 hasRelatedWork W108093282 @default.
- W2046963100 hasRelatedWork W1968811274 @default.
- W2046963100 hasRelatedWork W1985900017 @default.
- W2046963100 hasRelatedWork W1993837029 @default.
- W2046963100 hasRelatedWork W1998362519 @default.
- W2046963100 hasRelatedWork W2007577181 @default.
- W2046963100 hasRelatedWork W2051267793 @default.
- W2046963100 hasRelatedWork W2077720157 @default.
- W2046963100 hasRelatedWork W2352238251 @default.
- W2046963100 hasRelatedWork W2375916790 @default.
- W2046963100 hasVolume "326" @default.
- W2046963100 isParatext "false" @default.
- W2046963100 isRetracted "false" @default.
- W2046963100 magId "2046963100" @default.
- W2046963100 workType "article" @default.