FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046964197> ?p ?o ?g. }

• W2046964197 endingPage "15" @default.
• W2046964197 startingPage "1" @default.
• W2046964197 abstract "For parenteral biopharmaceuticals, subcutaneous diffusion and, in the case of solid implants or suspensions, dissolution may govern the clinical profile of the drug product. Insight into the dissolution and diffusion processes of biopharmaceuticals after parenteral administration is fundamental in the development of new protein drug formulations. Using insulin as a model compound, the aim of this work was to develop a UV imaging-based method to study the real-time dissolution and diffusion behavior of solid protein drugs under stagnant conditions in a hydrogel matrix mimicking the subcutaneous tissue. Dissolution of proteins and peptides is a complex phenomenon as it may be coupled to the complicated acid base properties of these substances. UV imaging allowed the real-time dissolution and diffusion processes of insulin at different pH values and of different insulins to be studied. Dissolution rates were obtained, and the quantitative performance of the developed UV imaging method was verified. It was shown that the UV imaging dissolution method was able to differentiate between the behavior of different insulins and that human insulin dissolution was highly dependent on pH. pH effects in the microenvironment of the human insulin compacts at pH 7.40 and 3.00 were observed by UV–Vis imaging, explaining the different dissolution kinetics of human insulin at pH 7.40 and 3.00 as compared to pH 5.40. In conclusion, UV–Vis imaging may be a useful tool for studying dissolution, diffusion and pH effects in the vicinity of solid protein drug in a hydrogel matrix with the aim of achieving a better understanding of in vivo dissolution processes." @default.
• W2046964197 created "2016-06-24" @default.
• W2046964197 creator A5062324035 @default.
• W2046964197 date "2006-02-01" @default.
• W2046964197 modified "2023-10-11" @default.
• W2046964197 title "Best literature values for the pK of carbonic and phosphoric acid under physiological conditions" @default.
• W2046964197 cites W155826860 @default.
• W2046964197 cites W1582229985 @default.
• W2046964197 cites W1595271694 @default.
• W2046964197 cites W1674216744 @default.
• W2046964197 cites W1681896432 @default.
• W2046964197 cites W1895895988 @default.
• W2046964197 cites W1923402636 @default.
• W2046964197 cites W19687437 @default.
• W2046964197 cites W1970682490 @default.
• W2046964197 cites W1976433952 @default.
• W2046964197 cites W2011411531 @default.
• W2046964197 cites W2030433104 @default.
• W2046964197 cites W2034673240 @default.
• W2046964197 cites W2056399508 @default.
• W2046964197 cites W2062470481 @default.
• W2046964197 cites W2068488138 @default.
• W2046964197 cites W2073238338 @default.
• W2046964197 cites W2073422693 @default.
• W2046964197 cites W2079439488 @default.
• W2046964197 cites W2083281321 @default.
• W2046964197 cites W2173978015 @default.
• W2046964197 cites W2237244627 @default.
• W2046964197 cites W2242316594 @default.
• W2046964197 cites W2282457111 @default.
• W2046964197 cites W2313107789 @default.
• W2046964197 cites W2313516597 @default.
• W2046964197 cites W2319706608 @default.
• W2046964197 cites W2320661767 @default.
• W2046964197 cites W2321780355 @default.
• W2046964197 cites W2322121514 @default.
• W2046964197 cites W2323189772 @default.
• W2046964197 cites W2324423385 @default.
• W2046964197 cites W2324827028 @default.
• W2046964197 cites W2333392762 @default.
• W2046964197 cites W2335180002 @default.
• W2046964197 cites W2335413432 @default.
• W2046964197 cites W2335613625 @default.
• W2046964197 cites W2410587357 @default.
• W2046964197 cites W2415487914 @default.
• W2046964197 cites W2432195370 @default.
• W2046964197 cites W4235178234 @default.
• W2046964197 cites W4240252293 @default.
• W2046964197 doi "https://doi.org/10.1016/j.ab.2005.08.020" @default.
• W2046964197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16376290" @default.
• W2046964197 hasPublicationYear "2006" @default.
• W2046964197 type Work @default.
• W2046964197 sameAs 2046964197 @default.
• W2046964197 citedByCount "21" @default.
• W2046964197 countsByYear W20469641972012 @default.
• W2046964197 countsByYear W20469641972013 @default.
• W2046964197 countsByYear W20469641972014 @default.
• W2046964197 countsByYear W20469641972015 @default.
• W2046964197 countsByYear W20469641972016 @default.
• W2046964197 countsByYear W20469641972017 @default.
• W2046964197 countsByYear W20469641972022 @default.
• W2046964197 crossrefType "journal-article" @default.
• W2046964197 hasAuthorship W2046964197A5062324035 @default.
• W2046964197 hasConcept C121332964 @default.
• W2046964197 hasConcept C126322002 @default.
• W2046964197 hasConcept C127413603 @default.
• W2046964197 hasConcept C148898269 @default.
• W2046964197 hasConcept C178790620 @default.
• W2046964197 hasConcept C185592680 @default.
• W2046964197 hasConcept C2779306644 @default.
• W2046964197 hasConcept C42360764 @default.
• W2046964197 hasConcept C43617362 @default.
• W2046964197 hasConcept C62520636 @default.
• W2046964197 hasConcept C69357855 @default.
• W2046964197 hasConcept C71924100 @default.
• W2046964197 hasConcept C88380143 @default.
• W2046964197 hasConcept C97355855 @default.
• W2046964197 hasConceptScore W2046964197C121332964 @default.
• W2046964197 hasConceptScore W2046964197C126322002 @default.
• W2046964197 hasConceptScore W2046964197C127413603 @default.
• W2046964197 hasConceptScore W2046964197C148898269 @default.
• W2046964197 hasConceptScore W2046964197C178790620 @default.
• W2046964197 hasConceptScore W2046964197C185592680 @default.
• W2046964197 hasConceptScore W2046964197C2779306644 @default.
• W2046964197 hasConceptScore W2046964197C42360764 @default.
• W2046964197 hasConceptScore W2046964197C43617362 @default.
• W2046964197 hasConceptScore W2046964197C62520636 @default.
• W2046964197 hasConceptScore W2046964197C69357855 @default.
• W2046964197 hasConceptScore W2046964197C71924100 @default.
• W2046964197 hasConceptScore W2046964197C88380143 @default.
• W2046964197 hasConceptScore W2046964197C97355855 @default.
• W2046964197 hasIssue "1" @default.
• W2046964197 hasLocation W20469641971 @default.
• W2046964197 hasLocation W20469641972 @default.
• W2046964197 hasOpenAccess W2046964197 @default.
• W2046964197 hasPrimaryLocation W20469641971 @default.
• W2046964197 hasRelatedWork W1971907849 @default.
• W2046964197 hasRelatedWork W1991785723 @default.

• next