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- W2046975498 abstract "Acetoxycycloheximide (AXM) or dibutyryl cyclic AMP (dbcAMP) was injected unilaterally into the vitreous humor of the eye beginning 5–6 days after bilateral optic nerve crush. Injections were repeated every 12–24 h for a total of 3–5 days; goldfish were sacrificed 10 days after lesioning the nerves. At a low dosage of AXM (0.1 μg daily for 5 days), the mean outgrowth distance in treated neurons was 60% less than in contralateral control neurons. At a high dosage (0.3 μg daily for 4 days), outgrowth was immediately blocked in both treated and contralateral control axons. Dibutyryl cyclic AMP, in a dose of 5 μM every 12 h for 3 days, produced a 38% reduction in outgrowth distance, associated with a 30% reduction in protein synthesis by the retinal ganglion cells and a 73% reduction in the amount of protein carried by the fast component of axonal transport." @default.
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- W2046975498 date "1983-11-01" @default.
- W2046975498 modified "2023-09-26" @default.
- W2046975498 title "Effect of acetoxycycloheximide and dibutyryladenosine cyclic3′:5′-monophosphate on axonal regeneration in the goldfish optic nerve" @default.
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- W2046975498 doi "https://doi.org/10.1016/0006-8993(83)90214-7" @default.
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