FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046979863> ?p ?o ?g. }

• W2046979863 endingPage "12" @default.
• W2046979863 startingPage "1" @default.
• W2046979863 abstract "In vitro systems have provided increasing evidence of significant lymphocyte transmembrane signalling by plasma membrane receptors which utilize antigen and other ligand activation of the inositol phosphate dual second messenger system of intracellular signalling. Elevation of intracellular Ca2+ and activation of protein kinase C are important products of these signals and appear to provide a complete set of mitogenic signals for both T and B cells. Calcium inophore and phorbol ester have been found to mimic these events in vitro and are here employed in vitro to study their effects on lymphocyte traffic and efferent lymph flow through primary peripheral lymph nodes of sheep and on the output into efferent lymph of the arachidonic acid metabolite, thromboxane B2. Calcium ionophore and phorbol ester were given alone or in combination to popliteal lymph nodes of sheep by drainage area injection or by acute infusion into cannulated afferent lympatics of study popliteal lymph nodes whose efferent lymphatic was chronically cannulated for study. The findings resembled those of drainage area immunization with an early increase in efferent lymph flow and prompt and marked depressions in the output into efferent lymph of both small recirculating and blast lymphocytes ('shutdown', 'recruitment'), followed by a marked increase in the output into efferent lymph of both small recirculating and blast lymphocytes. The greatest elevation in both small recirculating and blast lymphocyte outputs was at 24 and 48 h following phorbol ester and calcium ionophore administration. Acute phorbol ester and calcium ionophore administration was associated with a prompt and marked elevation in efferent lymph levels of thromboxane B2 which were of short duration. The findings observed here with lymph node drainage area infusion/injection of both phorbol ester and calcium ionophore are quite similar to those encountered in this sheep lymphocyte traffic model following popliteal lymph node drainage area immunization with killed Salmonella muenchen antigen." @default.
• W2046979863 created "2016-06-24" @default.
• W2046979863 creator A5054061002 @default.
• W2046979863 creator A5056841671 @default.
• W2046979863 creator A5072457191 @default.
• W2046979863 date "1991-01-01" @default.
• W2046979863 modified "2023-09-27" @default.
• W2046979863 title "In vivo influences of phorbol ester and calcium ionophore on lymphocyte traffic, lymph flow and efferent lymph levels of thromboxane B2 in sheep" @default.
• W2046979863 cites W1535884808 @default.
• W2046979863 cites W1802980406 @default.
• W2046979863 cites W1963831745 @default.
• W2046979863 cites W1972582980 @default.
• W2046979863 cites W1988985445 @default.
• W2046979863 cites W2001692359 @default.
• W2046979863 cites W2014898632 @default.
• W2046979863 cites W2016281377 @default.
• W2046979863 cites W2037867344 @default.
• W2046979863 cites W2039900664 @default.
• W2046979863 cites W2040970439 @default.
• W2046979863 cites W2060913566 @default.
• W2046979863 cites W2063898692 @default.
• W2046979863 cites W2064085834 @default.
• W2046979863 cites W2068877244 @default.
• W2046979863 cites W2085309680 @default.
• W2046979863 cites W2123141478 @default.
• W2046979863 cites W2176147791 @default.
• W2046979863 cites W2049502738 @default.
• W2046979863 doi "https://doi.org/10.1016/0162-3109(91)90002-g" @default.
• W2046979863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1860782" @default.
• W2046979863 hasPublicationYear "1991" @default.
• W2046979863 type Work @default.
• W2046979863 sameAs 2046979863 @default.
• W2046979863 citedByCount "1" @default.
• W2046979863 crossrefType "journal-article" @default.
• W2046979863 hasAuthorship W2046979863A5054061002 @default.
• W2046979863 hasAuthorship W2046979863A5056841671 @default.
• W2046979863 hasAuthorship W2046979863A5072457191 @default.
• W2046979863 hasConcept C126322002 @default.
• W2046979863 hasConcept C134018914 @default.
• W2046979863 hasConcept C142724271 @default.
• W2046979863 hasConcept C181080969 @default.
• W2046979863 hasConcept C185592680 @default.
• W2046979863 hasConcept C203014093 @default.
• W2046979863 hasConcept C2776512019 @default.
• W2046979863 hasConcept C2777761686 @default.
• W2046979863 hasConcept C2779014961 @default.
• W2046979863 hasConcept C2779263132 @default.
• W2046979863 hasConcept C2779720271 @default.
• W2046979863 hasConcept C2781080829 @default.
• W2046979863 hasConcept C519063684 @default.
• W2046979863 hasConcept C71924100 @default.
• W2046979863 hasConcept C86803240 @default.
• W2046979863 hasConcept C89560881 @default.
• W2046979863 hasConceptScore W2046979863C126322002 @default.
• W2046979863 hasConceptScore W2046979863C134018914 @default.
• W2046979863 hasConceptScore W2046979863C142724271 @default.
• W2046979863 hasConceptScore W2046979863C181080969 @default.
• W2046979863 hasConceptScore W2046979863C185592680 @default.
• W2046979863 hasConceptScore W2046979863C203014093 @default.
• W2046979863 hasConceptScore W2046979863C2776512019 @default.
• W2046979863 hasConceptScore W2046979863C2777761686 @default.
• W2046979863 hasConceptScore W2046979863C2779014961 @default.
• W2046979863 hasConceptScore W2046979863C2779263132 @default.
• W2046979863 hasConceptScore W2046979863C2779720271 @default.
• W2046979863 hasConceptScore W2046979863C2781080829 @default.
• W2046979863 hasConceptScore W2046979863C519063684 @default.
• W2046979863 hasConceptScore W2046979863C71924100 @default.
• W2046979863 hasConceptScore W2046979863C86803240 @default.
• W2046979863 hasConceptScore W2046979863C89560881 @default.
• W2046979863 hasIssue "1" @default.
• W2046979863 hasLocation W20469798631 @default.
• W2046979863 hasLocation W20469798632 @default.
• W2046979863 hasOpenAccess W2046979863 @default.
• W2046979863 hasPrimaryLocation W20469798631 @default.
• W2046979863 hasRelatedWork W1588928424 @default.
• W2046979863 hasRelatedWork W2003842308 @default.
• W2046979863 hasRelatedWork W2015853156 @default.
• W2046979863 hasRelatedWork W2049809574 @default.
• W2046979863 hasRelatedWork W2064236298 @default.
• W2046979863 hasRelatedWork W2066283776 @default.
• W2046979863 hasRelatedWork W2095093072 @default.
• W2046979863 hasRelatedWork W22320857 @default.
• W2046979863 hasRelatedWork W2409777197 @default.
• W2046979863 hasRelatedWork W2748952813 @default.
• W2046979863 hasVolume "21" @default.
• W2046979863 isParatext "false" @default.
• W2046979863 isRetracted "false" @default.
• W2046979863 magId "2046979863" @default.
• W2046979863 workType "article" @default.