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- W2046979903 abstract "Abstract Acute viral hepatitis B is cleared in more than 95% of patients, while the remainder ones may develop either chronic HBV infection or, rarely, fulminant hepatitis. Therefore there are elderly patients with severe acute HBV hepatitis caractherized by high serum bilirubin levels >15 mmole/dl, international normalized ratio (INR) with value more than 1.6; these patients are caractherized by a severe outcome of HBV infection. As known, outcome of infection and the pathogenesis of liver diseases are determined by viral and host factors, such as T reg lymphocytes. T regs may be associated with a negative immune response such as an inhibition of gamma- IFN secretion. The impact of viral load on antiviral T cell responses may play a critical role in thaese patients, influencing disease persistence and immune response. Antiviral drugs could be useful in these patients determing a possible down -regulation of T regs." @default.
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- W2046979903 date "2009-01-16" @default.
- W2046979903 modified "2023-10-03" @default.
- W2046979903 title "Antiviral therapy in acute viral hepatitis B: why and when" @default.
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- W2046979903 doi "https://doi.org/10.1186/1750-9378-4-2" @default.
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