FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046981282> ?p ?o ?g. }

• W2046981282 endingPage "215" @default.
• W2046981282 startingPage "209" @default.
• W2046981282 abstract "The C-terminal region of parathyroid hormone-related protein (PTHrP) containing the sequence (107-111) appears to be a potent inhibitor of osteoclastic bone resorption. In the present study, we have investigated the effect of human (h)PTHrP (107-139) and hPTHrP (107-111)NH2 on the proliferation of osteoblastic rat osteosarcoma UMR 106 cells. We found that both C-terminal PTHrP peptides, like hPTHrP (1-141), were antimitogenic for these cells, between 1 pM and 10 nM. [Tyr34]hPTHrP (1-34)NH2 was as potent as these peptides but less effective as growth inhibitor in these cells. UMR 106 cells were found to produce and secrete immunoreactive PTHrP. Addition of anti-PTHrP neutralizing antibodies to C- and N-terminal epitopes of PTHrP increased the growth of these cells. Our data suggest that the antiproliferative effect of these C-terminal PTHrP analogs may be independent of cyclic adenosine 3':5'-monophosphate (cAMP) and mediated by protein kinase C. These findings support an autocrine role of PTHrP in bone metabolism." @default.
• W2046981282 created "2016-06-24" @default.
• W2046981282 creator A5006140692 @default.
• W2046981282 creator A5048819945 @default.
• W2046981282 creator A5049672523 @default.
• W2046981282 creator A5065683911 @default.
• W2046981282 creator A5091874589 @default.
• W2046981282 date "1997-02-01" @default.
• W2046981282 modified "2023-10-18" @default.
• W2046981282 title "Antiproliferative effect of the C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), on osteoblastic osteosarcoma cells" @default.
• W2046981282 cites W1481438484 @default.
• W2046981282 cites W1757679215 @default.
• W2046981282 cites W1768192294 @default.
• W2046981282 cites W1972267776 @default.
• W2046981282 cites W1973454785 @default.
• W2046981282 cites W1975170728 @default.
• W2046981282 cites W1979514576 @default.
• W2046981282 cites W1980013295 @default.
• W2046981282 cites W1991674531 @default.
• W2046981282 cites W1994008003 @default.
• W2046981282 cites W1998034203 @default.
• W2046981282 cites W2007753723 @default.
• W2046981282 cites W2012122242 @default.
• W2046981282 cites W2017211434 @default.
• W2046981282 cites W2039975026 @default.
• W2046981282 cites W2043228935 @default.
• W2046981282 cites W2050183943 @default.
• W2046981282 cites W2054830866 @default.
• W2046981282 cites W2060487754 @default.
• W2046981282 cites W2061404820 @default.
• W2046981282 cites W2062264192 @default.
• W2046981282 cites W2065426268 @default.
• W2046981282 cites W2071470887 @default.
• W2046981282 cites W2072006115 @default.
• W2046981282 cites W2073884936 @default.
• W2046981282 cites W2075473225 @default.
• W2046981282 cites W2077082921 @default.
• W2046981282 cites W2088442866 @default.
• W2046981282 cites W2095426443 @default.
• W2046981282 cites W2096428903 @default.
• W2046981282 cites W2149445862 @default.
• W2046981282 cites W2159657237 @default.
• W2046981282 cites W2165919858 @default.
• W2046981282 cites W96218227 @default.
• W2046981282 doi "https://doi.org/10.1002/(sici)1097-4652(199702)170:2<209::aid-jcp13>3.0.co;2-c" @default.
• W2046981282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9009150" @default.
• W2046981282 hasPublicationYear "1997" @default.
• W2046981282 type Work @default.
• W2046981282 sameAs 2046981282 @default.
• W2046981282 citedByCount "57" @default.
• W2046981282 countsByYear W20469812822012 @default.
• W2046981282 countsByYear W20469812822015 @default.
• W2046981282 countsByYear W20469812822016 @default.
• W2046981282 countsByYear W20469812822017 @default.
• W2046981282 countsByYear W20469812822019 @default.
• W2046981282 countsByYear W20469812822020 @default.
• W2046981282 countsByYear W20469812822021 @default.
• W2046981282 countsByYear W20469812822022 @default.
• W2046981282 countsByYear W20469812822023 @default.
• W2046981282 crossrefType "journal-article" @default.
• W2046981282 hasAuthorship W2046981282A5006140692 @default.
• W2046981282 hasAuthorship W2046981282A5048819945 @default.
• W2046981282 hasAuthorship W2046981282A5049672523 @default.
• W2046981282 hasAuthorship W2046981282A5065683911 @default.
• W2046981282 hasAuthorship W2046981282A5091874589 @default.
• W2046981282 hasConcept C126322002 @default.
• W2046981282 hasConcept C128240485 @default.
• W2046981282 hasConcept C134018914 @default.
• W2046981282 hasConcept C170493617 @default.
• W2046981282 hasConcept C178790620 @default.
• W2046981282 hasConcept C185592680 @default.
• W2046981282 hasConcept C2776668983 @default.
• W2046981282 hasConcept C2776991684 @default.
• W2046981282 hasConcept C2777760704 @default.
• W2046981282 hasConcept C2778828131 @default.
• W2046981282 hasConcept C2781208988 @default.
• W2046981282 hasConcept C49039625 @default.
• W2046981282 hasConcept C502942594 @default.
• W2046981282 hasConcept C519063684 @default.
• W2046981282 hasConcept C55493867 @default.
• W2046981282 hasConcept C673006 @default.
• W2046981282 hasConcept C71924100 @default.
• W2046981282 hasConcept C86803240 @default.
• W2046981282 hasConceptScore W2046981282C126322002 @default.
• W2046981282 hasConceptScore W2046981282C128240485 @default.
• W2046981282 hasConceptScore W2046981282C134018914 @default.
• W2046981282 hasConceptScore W2046981282C170493617 @default.
• W2046981282 hasConceptScore W2046981282C178790620 @default.
• W2046981282 hasConceptScore W2046981282C185592680 @default.
• W2046981282 hasConceptScore W2046981282C2776668983 @default.
• W2046981282 hasConceptScore W2046981282C2776991684 @default.
• W2046981282 hasConceptScore W2046981282C2777760704 @default.
• W2046981282 hasConceptScore W2046981282C2778828131 @default.
• W2046981282 hasConceptScore W2046981282C2781208988 @default.
• W2046981282 hasConceptScore W2046981282C49039625 @default.
• W2046981282 hasConceptScore W2046981282C502942594 @default.
• W2046981282 hasConceptScore W2046981282C519063684 @default.
• W2046981282 hasConceptScore W2046981282C55493867 @default.

• next