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• W2047006564 abstract "Abstract Purpose: Various studies exploring the potential of the low‐molecular‐weight serum peptidome have identified proteolytic cleavage products of inter‐α‐trypsin inhibitor heavy chain‐4 (ITIH 4 ) as potential markers for different types of cancer, presumably generated by tumor‐associated exoproteases. However, further elucidation of the discriminative properties of such peptides requires specific quantitative analytical methods. Experimental design: Using a recently developed and fully validated liquid chromatography–tandem mass spectrometric method, we have compared absolute serum concentrations of eight peptides derived from ITIH 4 [658–687] to [667–687] (ITIH 4 ‐30 to −21) between breast cancer patients ( n =45) and controls ( n =78). Furthermore, serum samples obtained before and after surgical removal of the tumor were analyzed ( n =30). Results: The inter‐individual variability in measured serum concentrations was high. Nevertheless, most peptides showed a tendency toward elevated levels in the presence of the breast cancer tumor. Significantly increased serum concentrations were observed in the breast cancer group for ITIH 4 ‐25 ( p =0.036) and −29 ( p =0.015). Intra‐individual comparisons of serum obtained before and after surgery showed significantly decreased serum levels after surgery for seven of the ITIH 4 ‐derived peptides ( p <0.02). Conclusions and clinical relevance: The obtained results particularly suggest potential for these ITIH 4 ‐derived peptides in the follow‐up of breast cancer after surgery." @default.
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• W2047006564 date "2010-11-29" @default.
• W2047006564 modified "2023-10-07" @default.
• W2047006564 title "The absolute quantification of eight inter-α-trypsin inhibitor heavy chain 4 (ITIH4)-derived peptides in serum from breast cancer patients" @default.
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• W2047006564 doi "https://doi.org/10.1002/prca.201000035" @default.
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