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- W2047008207 abstract "Evaluation of: Kantoff PW, Higano CS, Shore ND et al.: Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N. Engl. J. Med. 363, 411–422 (2010). For many years, preclinical and clinical studies have attempted to harness the power of the immune system and focus it on malignant cells in an attempt to improve clinical outcomes for patients with cancer. This paper describes the landmark Phase III trial that led to the first US FDA approval of a therapeutic cancer vaccine. In a randomized trial of 512 patients, those treated with sipuleucel-T survived for 25.8 months compared with those treated with placebo, who survived 21.7 months (HR: 0.78; p = 0.03). There was, however, no change in time to progression, which may relate to the underlying mechanism of this new class of therapeutics." @default.
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- W2047008207 date "2011-01-01" @default.
- W2047008207 modified "2023-09-23" @default.
- W2047008207 title "Therapeutic cancer vaccine fulfills the promise of immunotherapy in prostate cancer" @default.
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- W2047008207 doi "https://doi.org/10.2217/imt.10.77" @default.
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