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- W2047020146 abstract "Spatial and temporal control of developing glomerular capillaries is complex and requires coordinated cross-talk between various cell types. Recent advances in our understanding of the processes that regulate glomerular morphogenesis reveal some mediators are essential for the emerging tuft, particularly vascular endothelial growth factor (VEGF) and PDGF.1–4In search of additional crucial mediators, Takabatake et al. 5 examine the role of CXC chemokine ligand 12 (CXCL12; stromal cell–derived factor 1 [SDF-1]) and its receptor, CXCR4, in this issue of JASN . Traditional SDF-1 signaling is involved primarily in the homing of hematopoietic stem cells to their niche within the bone marrow and in hematopoietic stem cell quiescence. A role for SDF-1/CXCR4 is also described for chemotaxis of T lymphocytes and monocytes, B cell development, cardiac and cerebellar development, and cancer stem cell migration.6 This study was triggered by a previous report, which analyzed mice deficient in SDF-1 or CXCR4 and the requirement for this ligand-receptor system in vascularization of the gastrointestinal tract.7 In their beautiful study, Takabatake et al. 5 demonstrate the SDF-1/CXCR4 axis is a novel and essential signaling system for blood vessel formation in the kidney, particularly within the glomerulus.The …" @default.
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- W2047020146 date "2009-08-01" @default.
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- W2047020146 title "The SDF-1/CXCR4 Axis Is a Novel Driver of Vascular Development of the Glomerulus" @default.
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- W2047020146 doi "https://doi.org/10.1681/asn.2009060621" @default.
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