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- W2047029989 abstract "Deoxycorticosterone acetate (DOCA) and 9α-fluorocortisol acetate (9α-F-Cac) can be modified by the introduction of a double bond at carbons 6 and 7 (6-dehydro-derivatives). Such a modification markedly changes the effect of the steroids on urinary excretion of Na+ and K+. Since 6–7 reduction of DOCA and 9α-F-Cac substantially reduces affinity for Type II receptors but not Type I receptors, 6-dehydro-derivatives will thus bind preferentially to receptors influencing the retention of sodium (the “mineralocorticoid” or Type I receptor), and compete with mineralocorticoids for such receptors. We interpret the increase in both natriuresis and kaliuresis when mineralocorticoids and their dehydro-derivatives are administered together as evidence for a Type II receptor mediation of these ion fluxes." @default.
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- W2047029989 title "Effect of 6-dehydro-doca and 6-dehydro-9αfluorocortisol acetate on the excretion of sodium and potassium in the rat" @default.
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- W2047029989 doi "https://doi.org/10.1016/0022-4731(85)90021-4" @default.
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