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- W2047030802 abstract "The present study was directed toward providing additional information in man on the nature of a potential alternative pathway to cholic acid not involving an initial 7α-hydroxylation of cholesterol. Two bile fistula patients and one normal subject each received 25-hydroxy[G-3H]cholesterol; [14C]cholic and [14C] chenodeoxycholic acids were also simultaneously administered to one bile fistula patient and normal subject. The labeled 25-hydroxycholesterol was found to be poorly converted to primary bile acids by all three patients; the range of conversion was 9.7 to 18.9%. Cholic acid was favored over chenodeoxycholic acid by a margin of about 1.4/1. It is concluded that a pathway to primary bile acid via the 25-hydroxylation of cholesterol is of minor importance under conditions of normal or accelerated synthesis in man." @default.
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- W2047030802 date "1981-01-01" @default.
- W2047030802 modified "2023-10-17" @default.
- W2047030802 title "A quantitative evaluation of the conversion of 25-hydroxycholesterol to bile acids in man" @default.
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- W2047030802 doi "https://doi.org/10.1016/0005-2760(81)90202-2" @default.
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