FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047033234> ?p ?o ?g. }

• W2047033234 endingPage "326" @default.
• W2047033234 startingPage "317" @default.
• W2047033234 abstract "Background Understanding the general mechanisms of sequence specific DNA recognition by proteins is a major challenge in structural biology. The existence of a ‘DNA recognition code’ for proteins, by which certain amino acid residues on a protein surface confer specificity for certain DNA bases, has been the subject of much discussion. However, no simple code has yet been established.Results The principles of DNA recognition can be described at two levels. The ‘chemical’ rules describe the partnerships between amino acid side chains and DNA bases making favourable interactions in the major groove of DNA. Here I analyze the occurrence of nucleotide–amino acid contacts in previously determined crystal structures of DNA–protein complexes and find that simple rules pertain. I also describe ‘stereochemical’ rules for the probe helix type of DNA-binding motif found in certain transcription factors including leucine zipper and homeodomain proteins. These are a consequence of the binding geometry, and specify the amino acid and base positions used for the contacts, and the sizes of residues in the contact interface.Conclusions The chemical rules can be generalized for any DNA-binding motif, while the stereochemical rules are specific to a particular DNA-binding motif. The recognition code for a particular binding motif can be described by combining the two sets of rules." @default.
• W2047033234 created "2016-06-24" @default.
• W2047033234 creator A5002282550 @default.
• W2047033234 date "1994-04-01" @default.
• W2047033234 modified "2023-10-16" @default.
• W2047033234 title "A framework for the DNA–protein recognition code of the probe helix in transcription factors: the chemical and stereochemical rules" @default.
• W2047033234 cites W1605119837 @default.
• W2047033234 cites W1809656640 @default.
• W2047033234 cites W1836912647 @default.
• W2047033234 cites W191042154 @default.
• W2047033234 cites W1974521227 @default.
• W2047033234 cites W1985459186 @default.
• W2047033234 cites W1986586522 @default.
• W2047033234 cites W1997329250 @default.
• W2047033234 cites W2000559841 @default.
• W2047033234 cites W2005144583 @default.
• W2047033234 cites W2005675760 @default.
• W2047033234 cites W2016328570 @default.
• W2047033234 cites W2026598193 @default.
• W2047033234 cites W2031762818 @default.
• W2047033234 cites W2032205265 @default.
• W2047033234 cites W2034457918 @default.
• W2047033234 cites W2037928324 @default.
• W2047033234 cites W2038003996 @default.
• W2047033234 cites W2038591490 @default.
• W2047033234 cites W2039478144 @default.
• W2047033234 cites W2041781038 @default.
• W2047033234 cites W2042708262 @default.
• W2047033234 cites W2042765757 @default.
• W2047033234 cites W2046278558 @default.
• W2047033234 cites W2050879305 @default.
• W2047033234 cites W2051141978 @default.
• W2047033234 cites W2054915217 @default.
• W2047033234 cites W2055166643 @default.
• W2047033234 cites W2056115277 @default.
• W2047033234 cites W2076849893 @default.
• W2047033234 cites W2077887022 @default.
• W2047033234 cites W2083710585 @default.
• W2047033234 cites W2086270305 @default.
• W2047033234 cites W2092171870 @default.
• W2047033234 cites W2098089372 @default.
• W2047033234 cites W2100715045 @default.
• W2047033234 cites W2102154371 @default.
• W2047033234 cites W2132185105 @default.
• W2047033234 cites W2132291850 @default.
• W2047033234 cites W2133335149 @default.
• W2047033234 cites W2147634528 @default.
• W2047033234 cites W2177861138 @default.
• W2047033234 cites W2482865254 @default.
• W2047033234 cites W29841679 @default.
• W2047033234 cites W4254085062 @default.
• W2047033234 cites W50469311 @default.
• W2047033234 doi "https://doi.org/10.1016/s0969-2126(00)00033-2" @default.
• W2047033234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8087558" @default.
• W2047033234 hasPublicationYear "1994" @default.
• W2047033234 type Work @default.
• W2047033234 sameAs 2047033234 @default.
• W2047033234 citedByCount "109" @default.
• W2047033234 countsByYear W20470332342012 @default.
• W2047033234 countsByYear W20470332342013 @default.
• W2047033234 countsByYear W20470332342014 @default.
• W2047033234 countsByYear W20470332342015 @default.
• W2047033234 countsByYear W20470332342016 @default.
• W2047033234 countsByYear W20470332342017 @default.
• W2047033234 countsByYear W20470332342018 @default.
• W2047033234 countsByYear W20470332342019 @default.
• W2047033234 countsByYear W20470332342020 @default.
• W2047033234 countsByYear W20470332342021 @default.
• W2047033234 countsByYear W20470332342022 @default.
• W2047033234 crossrefType "journal-article" @default.
• W2047033234 hasAuthorship W2047033234A5002282550 @default.
• W2047033234 hasBestOaLocation W20470332341 @default.
• W2047033234 hasConcept C101762097 @default.
• W2047033234 hasConcept C104317684 @default.
• W2047033234 hasConcept C10853874 @default.
• W2047033234 hasConcept C117745874 @default.
• W2047033234 hasConcept C150194340 @default.
• W2047033234 hasConcept C156860981 @default.
• W2047033234 hasConcept C185581394 @default.
• W2047033234 hasConcept C32010083 @default.
• W2047033234 hasConcept C3662595 @default.
• W2047033234 hasConcept C512185932 @default.
• W2047033234 hasConcept C515207424 @default.
• W2047033234 hasConcept C5179208 @default.
• W2047033234 hasConcept C54355233 @default.
• W2047033234 hasConcept C552990157 @default.
• W2047033234 hasConcept C55493867 @default.
• W2047033234 hasConcept C65556437 @default.
• W2047033234 hasConcept C70721500 @default.
• W2047033234 hasConcept C86339819 @default.
• W2047033234 hasConcept C86803240 @default.
• W2047033234 hasConcept C94966510 @default.
• W2047033234 hasConceptScore W2047033234C101762097 @default.
• W2047033234 hasConceptScore W2047033234C104317684 @default.
• W2047033234 hasConceptScore W2047033234C10853874 @default.
• W2047033234 hasConceptScore W2047033234C117745874 @default.
• W2047033234 hasConceptScore W2047033234C150194340 @default.
• W2047033234 hasConceptScore W2047033234C156860981 @default.

• next