Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047033263> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2047033263 endingPage "232" @default.
- W2047033263 startingPage "227" @default.
- W2047033263 abstract "Scopolamine has been used successfully for treatment of motion sickness for almost a century and the nasal administration was first studied 50 years ago. However, there never appeared a nasal dosage form. Finally, after finding a stable and suitable formulation for scopolamine, a study to investigate efficacy, safety, and tolerability was conducted, with a randomised, double-blind, double-dummy, crossover, Latin square design including placebo control and a placebo/placebo control for internal validity at the German Air Force Institute of Aviation Medicine. To assess the efficacy of a new, stable and well-tolerated formulation of scopolamine nasal spray the reproducible induction of whole body vibrations by a rotating chair was chosen and a validated seasickness score (SKS). The reduction of SKS showed that scopolamine nasal spray at a concentration of 0.2% was statistically superior to both placebo and dimenhydrinate (P=0.003 and 0.004, respectively). There were no signs for a nasal or epipharyngeal irritation of the mucous membrane. Scopolamine nasal spray was found to be an effective and safe treatment in motion sickness, with a fast onset of action within 30 min after administration." @default.
- W2047033263 created "2016-06-24" @default.
- W2047033263 creator A5003927700 @default.
- W2047033263 creator A5044463319 @default.
- W2047033263 creator A5059020000 @default.
- W2047033263 creator A5078257512 @default.
- W2047033263 date "2001-05-01" @default.
- W2047033263 modified "2023-09-26" @default.
- W2047033263 title "Scopolamine nasal spray in motion sickness: a randomised, controlled, and crossover study for the comparison of two scopolamine nasal sprays with oral dimenhydrinate and placebo" @default.
- W2047033263 cites W1964223766 @default.
- W2047033263 cites W2051560997 @default.
- W2047033263 cites W2108597157 @default.
- W2047033263 cites W2112167468 @default.
- W2047033263 cites W2313071345 @default.
- W2047033263 cites W2335421109 @default.
- W2047033263 cites W2410285692 @default.
- W2047033263 cites W4254730737 @default.
- W2047033263 doi "https://doi.org/10.1016/s0928-0987(01)00107-5" @default.
- W2047033263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11297908" @default.
- W2047033263 hasPublicationYear "2001" @default.
- W2047033263 type Work @default.
- W2047033263 sameAs 2047033263 @default.
- W2047033263 citedByCount "32" @default.
- W2047033263 countsByYear W20470332632012 @default.
- W2047033263 countsByYear W20470332632013 @default.
- W2047033263 countsByYear W20470332632014 @default.
- W2047033263 countsByYear W20470332632015 @default.
- W2047033263 countsByYear W20470332632017 @default.
- W2047033263 countsByYear W20470332632018 @default.
- W2047033263 countsByYear W20470332632019 @default.
- W2047033263 countsByYear W20470332632021 @default.
- W2047033263 countsByYear W20470332632022 @default.
- W2047033263 crossrefType "journal-article" @default.
- W2047033263 hasAuthorship W2047033263A5003927700 @default.
- W2047033263 hasAuthorship W2047033263A5044463319 @default.
- W2047033263 hasAuthorship W2047033263A5059020000 @default.
- W2047033263 hasAuthorship W2047033263A5078257512 @default.
- W2047033263 hasConcept C126838900 @default.
- W2047033263 hasConcept C142724271 @default.
- W2047033263 hasConcept C197934379 @default.
- W2047033263 hasConcept C203014093 @default.
- W2047033263 hasConcept C204787440 @default.
- W2047033263 hasConcept C27081682 @default.
- W2047033263 hasConcept C2777063393 @default.
- W2047033263 hasConcept C2778375690 @default.
- W2047033263 hasConcept C2778576352 @default.
- W2047033263 hasConcept C2779336972 @default.
- W2047033263 hasConcept C2780973058 @default.
- W2047033263 hasConcept C42219234 @default.
- W2047033263 hasConcept C46821324 @default.
- W2047033263 hasConcept C71924100 @default.
- W2047033263 hasConcept C85663871 @default.
- W2047033263 hasConcept C87813604 @default.
- W2047033263 hasConcept C98274493 @default.
- W2047033263 hasConceptScore W2047033263C126838900 @default.
- W2047033263 hasConceptScore W2047033263C142724271 @default.
- W2047033263 hasConceptScore W2047033263C197934379 @default.
- W2047033263 hasConceptScore W2047033263C203014093 @default.
- W2047033263 hasConceptScore W2047033263C204787440 @default.
- W2047033263 hasConceptScore W2047033263C27081682 @default.
- W2047033263 hasConceptScore W2047033263C2777063393 @default.
- W2047033263 hasConceptScore W2047033263C2778375690 @default.
- W2047033263 hasConceptScore W2047033263C2778576352 @default.
- W2047033263 hasConceptScore W2047033263C2779336972 @default.
- W2047033263 hasConceptScore W2047033263C2780973058 @default.
- W2047033263 hasConceptScore W2047033263C42219234 @default.
- W2047033263 hasConceptScore W2047033263C46821324 @default.
- W2047033263 hasConceptScore W2047033263C71924100 @default.
- W2047033263 hasConceptScore W2047033263C85663871 @default.
- W2047033263 hasConceptScore W2047033263C87813604 @default.
- W2047033263 hasConceptScore W2047033263C98274493 @default.
- W2047033263 hasIssue "2" @default.
- W2047033263 hasLocation W20470332631 @default.
- W2047033263 hasLocation W20470332632 @default.
- W2047033263 hasOpenAccess W2047033263 @default.
- W2047033263 hasPrimaryLocation W20470332631 @default.
- W2047033263 hasRelatedWork W2013290561 @default.
- W2047033263 hasRelatedWork W2019660771 @default.
- W2047033263 hasRelatedWork W2027351891 @default.
- W2047033263 hasRelatedWork W2047033263 @default.
- W2047033263 hasRelatedWork W2070697736 @default.
- W2047033263 hasRelatedWork W2071699883 @default.
- W2047033263 hasRelatedWork W2076100225 @default.
- W2047033263 hasRelatedWork W2398108179 @default.
- W2047033263 hasRelatedWork W2405579980 @default.
- W2047033263 hasRelatedWork W2513426503 @default.
- W2047033263 hasVolume "13" @default.
- W2047033263 isParatext "false" @default.
- W2047033263 isRetracted "false" @default.
- W2047033263 magId "2047033263" @default.
- W2047033263 workType "article" @default.