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• W2047043849 abstract "In a completely crossed, double blind designed study, six rats received intraventricular injections of 0.1, 1.0 and 10 micrograms of alpha-MSH and a placebo. The rats were tested for response to painful thermal stimuli with the tail-flick test. All of the doses of alpha-MSH produced hyperalgesia during the first 20 min of testing. Only the 1.0 microgram dose of alpha-MSH produced hyperalgesia throughout the 80 min course of the experiment. This study, coupled with previous reports that MSH/ACTH fragments may attenuate morphine-induced analgesia, suggest that MSH can have opposite actions from those of the endorphins. It is possible that alpha-MSH and related peptides may be endogenous anti-opiates." @default.
• W2047043849 created "2016-06-24" @default.
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• W2047043849 date "1981-06-01" @default.
• W2047043849 modified "2023-09-26" @default.
• W2047043849 title "Intraventricular administration of MSH induces hyperalgesia in rats" @default.
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• W2047043849 doi "https://doi.org/10.1016/s0196-9781(81)80040-x" @default.
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