FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047044177> ?p ?o ?g. }

• W2047044177 endingPage "10166" @default.
• W2047044177 startingPage "10157" @default.
• W2047044177 abstract "Glucagon-expressing retinal amacrine cells have been implicated in regulating postnatal ocular growth. Furthermore, experimentally accelerated rates of ocular growth increase the number of neurons added to the peripheral edge of the retina. Accordingly, we assayed whether glucagon-expressing neurons within the retina regulate the proliferation of progenitors in the circumferential marginal zone (CMZ) of the postnatal chicken eye. We found that glucagon-containing neurites are heavily clustered within the CMZ at the peripheral edge of the retina. Many of these neurites originate from a cell type that is distinct from other types of retinal neurons, which we termed large glucagon-expressing neurons (LGENs). The LGENs are immunoreactive for glucagon and glucagon-like peptide 1 (GLP1), have a unipolar morphology, produce an axon that projects into the CMZ, and are found only in ventral regions of the retina. In dorsal regions of the retina, a smaller version of the LGENs densely ramifies neurites in the CMZ. Intraocular injections of glucagon or GLP1 suppressed the proliferation of progenitors in the CMZ, whereas a glucagon-receptor antagonist promoted proliferation. In addition, we found that glucagon, GLP1, and glucagon antagonist influenced the number of progenitors in the CMZ. We conclude that the LGENs may convey visual information to the CMZ to control the addition of new cells to the edge of the retina. We propose that glucagon/GLP1 released from LGENs acts in opposition to insulin (or insulin-like growth factor) to regulate precisely the proliferation of retinal progenitors in the CMZ." @default.
• W2047044177 created "2016-06-24" @default.
• W2047044177 creator A5018415215 @default.
• W2047044177 creator A5023823329 @default.
• W2047044177 creator A5028155408 @default.
• W2047044177 creator A5063139808 @default.
• W2047044177 creator A5089148860 @default.
• W2047044177 date "2005-11-02" @default.
• W2047044177 modified "2023-09-30" @default.
• W2047044177 title "Glucagon-Expressing Neurons within the Retina Regulate the Proliferation of Neural Progenitors in the Circumferential Marginal Zone of the Avian Eye" @default.
• W2047044177 cites W1501026265 @default.
• W2047044177 cites W1556838748 @default.
• W2047044177 cites W1562809537 @default.
• W2047044177 cites W1568943792 @default.
• W2047044177 cites W1587507760 @default.
• W2047044177 cites W1909966762 @default.
• W2047044177 cites W1964270095 @default.
• W2047044177 cites W1970962746 @default.
• W2047044177 cites W1975480238 @default.
• W2047044177 cites W1978371504 @default.
• W2047044177 cites W1986727202 @default.
• W2047044177 cites W1986826218 @default.
• W2047044177 cites W2002115260 @default.
• W2047044177 cites W2007877980 @default.
• W2047044177 cites W2008529985 @default.
• W2047044177 cites W2016552437 @default.
• W2047044177 cites W2016580769 @default.
• W2047044177 cites W2019577657 @default.
• W2047044177 cites W2019775118 @default.
• W2047044177 cites W2031927234 @default.
• W2047044177 cites W2052537823 @default.
• W2047044177 cites W2061033163 @default.
• W2047044177 cites W2066729454 @default.
• W2047044177 cites W2067953064 @default.
• W2047044177 cites W2072836281 @default.
• W2047044177 cites W2077328589 @default.
• W2047044177 cites W2082855204 @default.
• W2047044177 cites W2084582407 @default.
• W2047044177 cites W2084644999 @default.
• W2047044177 cites W2085924238 @default.
• W2047044177 cites W2109876648 @default.
• W2047044177 cites W2114268866 @default.
• W2047044177 cites W2116425999 @default.
• W2047044177 cites W2148153820 @default.
• W2047044177 cites W2149380656 @default.
• W2047044177 cites W2153073720 @default.
• W2047044177 cites W2160391559 @default.
• W2047044177 cites W2166925879 @default.
• W2047044177 cites W2169344378 @default.
• W2047044177 cites W2410766690 @default.
• W2047044177 cites W4231019864 @default.
• W2047044177 cites W56644446 @default.
• W2047044177 cites W97293995 @default.
• W2047044177 doi "https://doi.org/10.1523/jneurosci.3247-05.2005" @default.
• W2047044177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6725792" @default.
• W2047044177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16267223" @default.
• W2047044177 hasPublicationYear "2005" @default.
• W2047044177 type Work @default.
• W2047044177 sameAs 2047044177 @default.
• W2047044177 citedByCount "44" @default.
• W2047044177 countsByYear W20470441772012 @default.
• W2047044177 countsByYear W20470441772013 @default.
• W2047044177 countsByYear W20470441772014 @default.
• W2047044177 countsByYear W20470441772015 @default.
• W2047044177 countsByYear W20470441772016 @default.
• W2047044177 countsByYear W20470441772017 @default.
• W2047044177 countsByYear W20470441772018 @default.
• W2047044177 countsByYear W20470441772019 @default.
• W2047044177 countsByYear W20470441772021 @default.
• W2047044177 countsByYear W20470441772022 @default.
• W2047044177 crossrefType "journal-article" @default.
• W2047044177 hasAuthorship W2047044177A5018415215 @default.
• W2047044177 hasAuthorship W2047044177A5023823329 @default.
• W2047044177 hasAuthorship W2047044177A5028155408 @default.
• W2047044177 hasAuthorship W2047044177A5063139808 @default.
• W2047044177 hasAuthorship W2047044177A5089148860 @default.
• W2047044177 hasBestOaLocation W20470441771 @default.
• W2047044177 hasConcept C113246987 @default.
• W2047044177 hasConcept C126322002 @default.
• W2047044177 hasConcept C134018914 @default.
• W2047044177 hasConcept C169760540 @default.
• W2047044177 hasConcept C201750760 @default.
• W2047044177 hasConcept C202751555 @default.
• W2047044177 hasConcept C2777093970 @default.
• W2047044177 hasConcept C2778563252 @default.
• W2047044177 hasConcept C2779306644 @default.
• W2047044177 hasConcept C2780827179 @default.
• W2047044177 hasConcept C28328180 @default.
• W2047044177 hasConcept C54355233 @default.
• W2047044177 hasConcept C55493867 @default.
• W2047044177 hasConcept C71924100 @default.
• W2047044177 hasConcept C86803240 @default.
• W2047044177 hasConcept C95444343 @default.
• W2047044177 hasConceptScore W2047044177C113246987 @default.
• W2047044177 hasConceptScore W2047044177C126322002 @default.
• W2047044177 hasConceptScore W2047044177C134018914 @default.
• W2047044177 hasConceptScore W2047044177C169760540 @default.
• W2047044177 hasConceptScore W2047044177C201750760 @default.

• next