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- W2047044550 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILNucleus accumbens-associated protein 1 (NAC1) is a member of the BTB (Bric-a-Brac Tramtrack Broad complex) family of proteins. Recent studies have demonstrated NAC1 expression is essential for sustaining cancer cell proliferation and migration, but its molecular mechanisms remain elusive. In this report, we show that NAC1 is an actin monomer binding protein with a Kd of 0.78 μM, and the BTB domain is the actin-binding domain. Disrupting NAC1 protein complex function using a dominant-negative construct or RNA-interference resulted in reduced traction and incomplete abscission during late stage cytokinesis leading to multi-nucleation of cancer cells. We examined the phenotype of Nac1 knockout mice, and discovered the loss in expression of the Nac1 protein led to a patterning defect of the vertebral skeletal axis. Nac1-null mice were correlated with morphological transformation of the sixth lumbar vertebra into a sacral identity; a decreased total number of pre-sacral vertebrae elements from 26 in wild type mice to 25. Taken together, we explored the role of NAC1 as an actin binding protein essential for the cytokinesis of cancer cells, and its effects on patterning of the murine vertebral axis. These findings advance our knowledge of this physiologically-relevant protein in the field of mammalian development and cancer biology.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-115. doi:1538-7445.AM2012-LB-115" @default.
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- W2047044550 date "2012-04-15" @default.
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- W2047044550 title "Abstract LB-115: NAC1 is an actin binding protein essential for the cytokinesis of cancer cells and plays a role in the patterning of murine vertebral axis" @default.
- W2047044550 doi "https://doi.org/10.1158/1538-7445.am2012-lb-115" @default.
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