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• W2047045426 abstract "We have investigated phenol replacements in a series of diaryl amino piperidine delta opioid agonists. From this study we have demonstrated that the hydroxy functional group can be replaced with a primary amide group, giving enhanced activity at the delta receptor, increased selectivity versus mu and kappa as well as improved in vitro metabolic stability." @default.
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• W2047045426 date "2009-11-01" @default.
• W2047045426 modified "2023-09-23" @default.
• W2047045426 title "Delta agonist hydroxy bioisosteres: The discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability" @default.
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• W2047045426 doi "https://doi.org/10.1016/j.bmcl.2009.09.068" @default.
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