Matches in SemOpenAlex for { <https://semopenalex.org/work/W204704633> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W204704633 endingPage "58" @default.
- W204704633 startingPage "1147" @default.
- W204704633 abstract "Sex differences in the nervous system are prevalent throughout the animal kingdom. In humans, the corpus callosum and anterior commissure are larger in females, whereas some hypothalamic nuclei and associated structures are larger in males. Numerous studies in rodents have demonstrated that when these nuclei are exposed to circulating androgens during the critical period around birth, they develop into male-typical structures. In addition to this organizational effect, androgens exert an activational effect during adulthood. For example, sexually dimorphic gene expression in the hypothalamus and amygdala depends on circulating androgen levels. Cckar encodes a G protein-coupled receptor and its expression is sexually dimorphic. The major of Cckar-expressing neurons in the ventrolateral division of ventromedial hypothalamus (VMHvl) also express progesterone receptor (PR), with a female-biased expansion of arborizations in the anteroventral periventricular hypothalamic nucleus. Selective ablation of these PR-positive neurons in the VMHvl results in a marked reduction in female sexual receptivity and male aggression, demonstrating that these sexually dimorphic neurons contribute to gendered behavior in mammals. Remarkable sex differences in single neurons have been documented in the fruitfly (Drosophila melanogaster). The fruitless (fru) gene in the fruitfly is considered as a major regulator of male courtship circuitry; a male specific fru-expressing neuron cluster, P1, can initiate male courtship when artificially activated even in the absence of courtship target (e.g., a female). The fru gene encodes a set of putative transcription factors that appear to orchestrate the transcription of ~100 genes by recruiting chromatin regulators, histone deacetylase 1 or heterochromatin protein 1a, to the target sites. These studies have unraveled the causal link among genes, brain sexual dimorphisms and gendered behaviors." @default.
- W204704633 created "2016-06-24" @default.
- W204704633 creator A5044442723 @default.
- W204704633 creator A5077430218 @default.
- W204704633 date "2013-10-01" @default.
- W204704633 modified "2023-10-18" @default.
- W204704633 title "[The female brain and the male brain]." @default.
- W204704633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24101426" @default.
- W204704633 hasPublicationYear "2013" @default.
- W204704633 type Work @default.
- W204704633 sameAs 204704633 @default.
- W204704633 citedByCount "1" @default.
- W204704633 countsByYear W2047046332017 @default.
- W204704633 crossrefType "journal-article" @default.
- W204704633 hasAuthorship W204704633A5044442723 @default.
- W204704633 hasAuthorship W204704633A5077430218 @default.
- W204704633 hasConcept C104317684 @default.
- W204704633 hasConcept C105083479 @default.
- W204704633 hasConcept C121608353 @default.
- W204704633 hasConcept C126322002 @default.
- W204704633 hasConcept C134018914 @default.
- W204704633 hasConcept C169760540 @default.
- W204704633 hasConcept C2776046087 @default.
- W204704633 hasConcept C2776453541 @default.
- W204704633 hasConcept C2776514529 @default.
- W204704633 hasConcept C2777003273 @default.
- W204704633 hasConcept C2780192828 @default.
- W204704633 hasConcept C54355233 @default.
- W204704633 hasConcept C54458228 @default.
- W204704633 hasConcept C61367390 @default.
- W204704633 hasConcept C67705224 @default.
- W204704633 hasConcept C71924100 @default.
- W204704633 hasConcept C86803240 @default.
- W204704633 hasConcept C90856448 @default.
- W204704633 hasConceptScore W204704633C104317684 @default.
- W204704633 hasConceptScore W204704633C105083479 @default.
- W204704633 hasConceptScore W204704633C121608353 @default.
- W204704633 hasConceptScore W204704633C126322002 @default.
- W204704633 hasConceptScore W204704633C134018914 @default.
- W204704633 hasConceptScore W204704633C169760540 @default.
- W204704633 hasConceptScore W204704633C2776046087 @default.
- W204704633 hasConceptScore W204704633C2776453541 @default.
- W204704633 hasConceptScore W204704633C2776514529 @default.
- W204704633 hasConceptScore W204704633C2777003273 @default.
- W204704633 hasConceptScore W204704633C2780192828 @default.
- W204704633 hasConceptScore W204704633C54355233 @default.
- W204704633 hasConceptScore W204704633C54458228 @default.
- W204704633 hasConceptScore W204704633C61367390 @default.
- W204704633 hasConceptScore W204704633C67705224 @default.
- W204704633 hasConceptScore W204704633C71924100 @default.
- W204704633 hasConceptScore W204704633C86803240 @default.
- W204704633 hasConceptScore W204704633C90856448 @default.
- W204704633 hasIssue "10" @default.
- W204704633 hasLocation W2047046331 @default.
- W204704633 hasOpenAccess W204704633 @default.
- W204704633 hasPrimaryLocation W2047046331 @default.
- W204704633 hasRelatedWork W1955310396 @default.
- W204704633 hasRelatedWork W1972357399 @default.
- W204704633 hasRelatedWork W1990049659 @default.
- W204704633 hasRelatedWork W2035740905 @default.
- W204704633 hasRelatedWork W2037648264 @default.
- W204704633 hasRelatedWork W2048298728 @default.
- W204704633 hasRelatedWork W2074178193 @default.
- W204704633 hasRelatedWork W2112726699 @default.
- W204704633 hasRelatedWork W2130932099 @default.
- W204704633 hasRelatedWork W2315166476 @default.
- W204704633 hasVolume "65" @default.
- W204704633 isParatext "false" @default.
- W204704633 isRetracted "false" @default.
- W204704633 magId "204704633" @default.
- W204704633 workType "article" @default.