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• W2047048172 abstract "Introduction Analyse de l’efficacite et de la tolerance des implants de carmustine (Gliadel ® ) deposes lors d’une exerese en association avec le protocole Stupp pour le traitement de premiere intention des glioblastomes supratentoriels de l’adulte nouvellement diagnostiques.’ Materiel/methode Etude cas-temoin et etude appariee en score de propension chez 787 glioblastomes avec (groupe Implantation) et sans (groupe Standard) implantation de Gliadel ® en association avec le protocole Stupp. Resultats La survie sans progression mediane etait de 12,0 mois (95 % CI 10,7–12,6) dans le groupe implantation et de 10,0 mois (95 % CI : 9,0–10,0) dans le groupe standard. Le hazard ratio de progression tumorale dans le groupe implantation en comparaison du groupe standard etait de 0,81 (95 % CI 0,69–0,94 ; p  = 0,004) dans l’etude cas-temoin et de 0,78 (95 % CI 0,63–0,95 ; p  = 0,016) dans l’etude appariee. La survie globable mediane etait de 21,0 mois (95 % CI 19,7–23,4) chez les patients ayant eu du Gliadel ® au cours de l’evolution de la maladie (en premiere intention et/ou en recidive) et de 17,6 mois (95 % CI 16,0–19,0) chez les patients n’en ayant jamais eu. Le hazard ratio de deces dans le groupe ayant eu du Gliadel ® au cours de l’evolution de leur maladie en comparaison du groupe n’en ayant jamais etait de 0,76 (95 % CI 0,65–0,90 ; p  = 0,001) dans l’etude cas-temoin et de 0,73 (95 % CI 0,62–0,86 ; p p Conclusion L’implantation peroperatoire de Gliadel ® au cours d’une chirurgie de resection large associee au protocole Stupp pour le traitement de premiere intention des glioblastomes offre un gain de survie significatif avec une tolerance acceptable." @default.
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• W2047048172 date "2014-12-01" @default.
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• W2047048172 title "Long-term results of carmustine wafers implantation for newly-diagnosed glioblastomas in France: Controlled propensity matched multicenter cohort study" @default.
• W2047048172 doi "https://doi.org/10.1016/j.neuchi.2014.10.026" @default.
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