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- W2047055875 abstract "Application of the alkane n -dodecane to the dorsal skin of 6–8 week old female SENCAR mice initiated with 10 nmol dimethylbenz[ a ]anthracene led to papilloma formation in the majority of treated animals. Compared to the potent phorbol diester 12- O -tetradecanoylphorbol-13-acetate (TPA), n -dodecane was several orders of magnitude less potent on a dose basis, and maximal papilloma response required more extended application (22 weeks for 50 mg dodecane compared to 12 weeks for 2 μg TPA). In two-stage promotion experiments n -dodecane appeared to act as a stage II promoting agent at appropriate doses, being comparable in activity to mezerein—an agent with well-characterized activity of this type. Dodecane, unlike mezerein, did not induce the formation of a significant number of pyknotic cells, however, suggesting that the weak promoting activity of dodecane in stage 1 was not a result of toxicity. In comparison with TPA, both mezerein and n -dodecane at promoting doses induced lesa sustained hyperplasia in SENCAR mouse skin, a finding also consistent with the proposal that n -dodecane is principally active in stage II of two-stage promotion models. Both agents induced ornithine decarboxylase activity in SENCAR mouse skin, the maximal induction being observed at apparently the same time after a single application." @default.
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- W2047055875 date "1987-01-01" @default.
- W2047055875 modified "2023-09-23" @default.
- W2047055875 title "Mechanism of mouse skin tumor promotion by <i>n</i>-dodecane" @default.
- W2047055875 doi "https://doi.org/10.1093/carcin/8.12.1787" @default.
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