Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047066341> ?p ?o ?g. }
- W2047066341 endingPage "696" @default.
- W2047066341 startingPage "683" @default.
- W2047066341 abstract "The type I TGFβ family member receptor alk8 acts in bone morphogenetic protein (BMP) signaling pathways to establish dorsoventral patterning in the early zebrafish embryo. Here, we present evidence that alk8 is required for neural crest cell (NCC) formation and that alk8 signaling gradients direct the proper patterning of premigratory NCCs. We extend our previous functional studies of alk8 to demonstrate that ectopic expression of constitutively active and dominant negative Alk8, consistently results in more medially or laterally positioned premigratory NCCs, respectively. We also demonstrate that patterning defects in premigratory NCCs, induced by alk8 misexpression, correlate with subsequent defects in NCC-derived pharyngeal arch cartilages. Furthermore, an anteroposterior effect is revealed, where overexpression of Alk8 more severely affects anterior arch cartilages and decreased Alk8 activity more severely affects posterior arch cartilage formation. Ectopic expression studies of alk8 are supported by analyses of zygotic and maternal-zygotic laf/alk8 mutants and of several BMP pathway mutants. Pharyngeal mesodermal and endodermal defects in laf/alk8 mutants suggest additional roles for alk8 in patterning of these tissues. Our results provide insight into alk8-mediated BMP signaling gradients and the establishment of premigratory NCC mediolateral positioning, and extend the model for BMP patterning of the neural crest to include that of NCC-derived pharyngeal arch cartilages. Developmental Dynamics 228:683–696, 2003. © 2003 Wiley-Liss, Inc." @default.
- W2047066341 created "2016-06-24" @default.
- W2047066341 creator A5006931548 @default.
- W2047066341 creator A5068312032 @default.
- W2047066341 date "2003-11-24" @default.
- W2047066341 modified "2023-10-09" @default.
- W2047066341 title "Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages" @default.
- W2047066341 cites W1494055834 @default.
- W2047066341 cites W1547869018 @default.
- W2047066341 cites W1565566882 @default.
- W2047066341 cites W1821374357 @default.
- W2047066341 cites W1851488602 @default.
- W2047066341 cites W1879493681 @default.
- W2047066341 cites W1902976989 @default.
- W2047066341 cites W1906437714 @default.
- W2047066341 cites W1929503316 @default.
- W2047066341 cites W1952870715 @default.
- W2047066341 cites W1958621441 @default.
- W2047066341 cites W1973497708 @default.
- W2047066341 cites W1974723367 @default.
- W2047066341 cites W1982291928 @default.
- W2047066341 cites W1984288177 @default.
- W2047066341 cites W1984766519 @default.
- W2047066341 cites W1986117279 @default.
- W2047066341 cites W1986469118 @default.
- W2047066341 cites W1992038523 @default.
- W2047066341 cites W1992533419 @default.
- W2047066341 cites W1992778213 @default.
- W2047066341 cites W1995511868 @default.
- W2047066341 cites W1998365428 @default.
- W2047066341 cites W2012634492 @default.
- W2047066341 cites W2014160598 @default.
- W2047066341 cites W2014536457 @default.
- W2047066341 cites W2016686483 @default.
- W2047066341 cites W2018820156 @default.
- W2047066341 cites W2022906661 @default.
- W2047066341 cites W2025168331 @default.
- W2047066341 cites W2037397876 @default.
- W2047066341 cites W2040773128 @default.
- W2047066341 cites W2045008166 @default.
- W2047066341 cites W2047462832 @default.
- W2047066341 cites W2048020747 @default.
- W2047066341 cites W2050614371 @default.
- W2047066341 cites W2055110202 @default.
- W2047066341 cites W2066021890 @default.
- W2047066341 cites W2066092773 @default.
- W2047066341 cites W2066665326 @default.
- W2047066341 cites W2068279595 @default.
- W2047066341 cites W2075256267 @default.
- W2047066341 cites W2075695134 @default.
- W2047066341 cites W2079521227 @default.
- W2047066341 cites W2081748379 @default.
- W2047066341 cites W2091760375 @default.
- W2047066341 cites W2092344861 @default.
- W2047066341 cites W2092911887 @default.
- W2047066341 cites W2111350290 @default.
- W2047066341 cites W2115799477 @default.
- W2047066341 cites W2121959203 @default.
- W2047066341 cites W2122920636 @default.
- W2047066341 cites W2122952423 @default.
- W2047066341 cites W2124357826 @default.
- W2047066341 cites W2124916682 @default.
- W2047066341 cites W2125161163 @default.
- W2047066341 cites W2129537171 @default.
- W2047066341 cites W2141405756 @default.
- W2047066341 cites W2141614336 @default.
- W2047066341 cites W2147245058 @default.
- W2047066341 cites W2149417485 @default.
- W2047066341 cites W2149771940 @default.
- W2047066341 cites W2157444265 @default.
- W2047066341 cites W2158071345 @default.
- W2047066341 cites W2161993735 @default.
- W2047066341 cites W2164386538 @default.
- W2047066341 cites W2182011057 @default.
- W2047066341 cites W2185661130 @default.
- W2047066341 cites W2215211951 @default.
- W2047066341 cites W4296588288 @default.
- W2047066341 doi "https://doi.org/10.1002/dvdy.10417" @default.
- W2047066341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14648845" @default.
- W2047066341 hasPublicationYear "2003" @default.
- W2047066341 type Work @default.
- W2047066341 sameAs 2047066341 @default.
- W2047066341 citedByCount "18" @default.
- W2047066341 countsByYear W20470663412012 @default.
- W2047066341 countsByYear W20470663412013 @default.
- W2047066341 countsByYear W20470663412015 @default.
- W2047066341 crossrefType "journal-article" @default.
- W2047066341 hasAuthorship W2047066341A5006931548 @default.
- W2047066341 hasAuthorship W2047066341A5068312032 @default.
- W2047066341 hasConcept C104317684 @default.
- W2047066341 hasConcept C105702510 @default.
- W2047066341 hasConcept C126749454 @default.
- W2047066341 hasConcept C143065580 @default.
- W2047066341 hasConcept C145103041 @default.
- W2047066341 hasConcept C196843134 @default.
- W2047066341 hasConcept C2776878037 @default.
- W2047066341 hasConcept C31507581 @default.
- W2047066341 hasConcept C54355233 @default.