FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047069622> ?p ?o ?g. }

• W2047069622 endingPage "29" @default.
• W2047069622 startingPage "24" @default.
• W2047069622 abstract "Promising studies suggest that defects in synaptic plasticity detected in schizophrenia may be linked to neurodevelopmental and neurodegenerative abnormalities and contribute to disease-associated cognitive impairment. We aimed to clarify the role of the synaptic plasticity regulatory proteins, nerve growth factor (NGF) and its receptor (NGFR) in the pathogenesis of schizophrenia by comparative analysis of their blood levels and functional single nucleotide polymorphisms (SNPs) in genes encoding these proteins (NGF and NGFR) in schizophrenia-affected and healthy subjects. Relationships between the selected SNPs' genotypes and NGF and NGFR plasma levels were also assessed. Our results demonstrated a positive association between schizophrenia and the NGF rs6330 as well as the NGFR rs11466155 and rs2072446 SNPs. Also, a negative association between this disorder and NGF rs4839435 as well as NGFR rs734194 was found. In both, haloperidol-treated and antipsychotic-free patients decreased blood levels of the NGF and NGFR were found, and a positive interrelation between rs6330 and rs2072446 carriage and decreased NGF and NGFR levels, respectively, was revealed. In conclusion, our results demonstrate association of schizophrenia with the rs6330, rs4839435 and rs734194, rs11466155, rs2072446 as well as with the decreased blood levels of corresponding proteins. Our findings indicate the implication of alterations in NGFR and NGFR genes in schizophrenia, particularly, in defects of synaptic plasticity. Furthermore, the data obtained suggests that at least in Armenian population the NGF rs6330*T and NGFR rs11466155*T, rs2072446*T alleles might be nominated as risk factors, whereas the NGF rs4839435*A and NGFR rs734194*G alleles might be protective against developing schizophrenia." @default.
• W2047069622 created "2016-06-24" @default.
• W2047069622 creator A5037983218 @default.
• W2047069622 creator A5068786781 @default.
• W2047069622 creator A5075882805 @default.
• W2047069622 creator A5085487411 @default.
• W2047069622 date "2014-06-01" @default.
• W2047069622 modified "2023-10-14" @default.
• W2047069622 title "Nerve growth factor and its receptor in schizophrenia" @default.
• W2047069622 cites W1487796157 @default.
• W2047069622 cites W1521573047 @default.
• W2047069622 cites W152417155 @default.
• W2047069622 cites W1542816299 @default.
• W2047069622 cites W1976774853 @default.
• W2047069622 cites W1990196033 @default.
• W2047069622 cites W1993410155 @default.
• W2047069622 cites W1998679999 @default.
• W2047069622 cites W2005942879 @default.
• W2047069622 cites W2008886334 @default.
• W2047069622 cites W2009274120 @default.
• W2047069622 cites W2009918823 @default.
• W2047069622 cites W2010873112 @default.
• W2047069622 cites W2010907110 @default.
• W2047069622 cites W2013131099 @default.
• W2047069622 cites W2014204077 @default.
• W2047069622 cites W2016717347 @default.
• W2047069622 cites W2019004374 @default.
• W2047069622 cites W2021391251 @default.
• W2047069622 cites W2023314433 @default.
• W2047069622 cites W2025027835 @default.
• W2047069622 cites W2035976682 @default.
• W2047069622 cites W2042727575 @default.
• W2047069622 cites W2045449112 @default.
• W2047069622 cites W2046645276 @default.
• W2047069622 cites W2048327980 @default.
• W2047069622 cites W2055597695 @default.
• W2047069622 cites W2058401000 @default.
• W2047069622 cites W2061081311 @default.
• W2047069622 cites W2074514459 @default.
• W2047069622 cites W2080935783 @default.
• W2047069622 cites W2092534691 @default.
• W2047069622 cites W2097071826 @default.
• W2047069622 cites W2103560303 @default.
• W2047069622 cites W2112689297 @default.
• W2047069622 cites W2113795250 @default.
• W2047069622 cites W2114908592 @default.
• W2047069622 cites W2117003890 @default.
• W2047069622 cites W2117633779 @default.
• W2047069622 cites W2119525425 @default.
• W2047069622 cites W2125648698 @default.
• W2047069622 cites W2131920027 @default.
• W2047069622 cites W2135140935 @default.
• W2047069622 cites W2143835734 @default.
• W2047069622 cites W2151200519 @default.
• W2047069622 cites W2156184193 @default.
• W2047069622 cites W2156286194 @default.
• W2047069622 cites W2157571916 @default.
• W2047069622 cites W2159697434 @default.
• W2047069622 cites W2161670346 @default.
• W2047069622 cites W2161969259 @default.
• W2047069622 cites W2163639252 @default.
• W2047069622 cites W2165710695 @default.
• W2047069622 cites W2337729957 @default.
• W2047069622 cites W2416357576 @default.
• W2047069622 doi "https://doi.org/10.1016/j.bbacli.2014.05.001" @default.
• W2047069622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4633968" @default.
• W2047069622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26675984" @default.
• W2047069622 hasPublicationYear "2014" @default.
• W2047069622 type Work @default.
• W2047069622 sameAs 2047069622 @default.
• W2047069622 citedByCount "45" @default.
• W2047069622 countsByYear W20470696222014 @default.
• W2047069622 countsByYear W20470696222015 @default.
• W2047069622 countsByYear W20470696222016 @default.
• W2047069622 countsByYear W20470696222017 @default.
• W2047069622 countsByYear W20470696222018 @default.
• W2047069622 countsByYear W20470696222019 @default.
• W2047069622 countsByYear W20470696222020 @default.
• W2047069622 countsByYear W20470696222021 @default.
• W2047069622 countsByYear W20470696222022 @default.
• W2047069622 countsByYear W20470696222023 @default.
• W2047069622 crossrefType "journal-article" @default.
• W2047069622 hasAuthorship W2047069622A5037983218 @default.
• W2047069622 hasAuthorship W2047069622A5068786781 @default.
• W2047069622 hasAuthorship W2047069622A5075882805 @default.
• W2047069622 hasAuthorship W2047069622A5085487411 @default.
• W2047069622 hasBestOaLocation W20470696221 @default.
• W2047069622 hasConcept C104317684 @default.
• W2047069622 hasConcept C118552586 @default.
• W2047069622 hasConcept C126322002 @default.
• W2047069622 hasConcept C134018914 @default.
• W2047069622 hasConcept C135763542 @default.
• W2047069622 hasConcept C153209595 @default.
• W2047069622 hasConcept C170493617 @default.
• W2047069622 hasConcept C2776412080 @default.
• W2047069622 hasConcept C2778423431 @default.
• W2047069622 hasConcept C2780942790 @default.
• W2047069622 hasConcept C54355233 @default.

• next