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- W2047079327 abstract "The protein kinase CDK5 was originally discovered at a time when cyclin-dependent kinases were thought to be involved exclusively in cell cycle control. The CDK5 catalytic subunit was first identified based on its nucleotide sequence homology to other known CDK family members (cdc2, CDK2),1 while the enzyme activity was identified by protein purification of a tau kinase relevant to Alzheimer disease2 and, independently, of a novel kinase exhibiting cdc2-like substrate specificity in brain.3 These activities were referred to as tau kinase II and brain proline-directed kinase, respectively, which, upon purification were shown to be one and the same enzyme. In addition to isolation of the active form of CDK5, purification revealed a bound p25 regulatory subunit of novel sequence, and molecular cloning revealed the full-length precursor of this subunit, p35.4" @default.
- W2047079327 created "2016-06-24" @default.
- W2047079327 creator A5072292956 @default.
- W2047079327 date "2013-07-01" @default.
- W2047079327 modified "2023-09-26" @default.
- W2047079327 title "CDK5: A new lead to survival" @default.
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- W2047079327 doi "https://doi.org/10.4161/cc.25304" @default.
- W2047079327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3737291" @default.
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