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• W2047102030 endingPage "5952" @default.
• W2047102030 startingPage "5947" @default.
• W2047102030 abstract "The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during aging. The proteasome also acts in a regulatory capacity through E3 ligases to mediate the spatially and temporally controlled breakdown of specific proteins that impact biological processes. We have identified components of a Skp1-Cul1-F-Box E3 ligase complex that are required for the extended lifespan of Caenorhabditis elegans insulin/insulin-like growth factor-1-signaling (IIS) mutants. The CUL-1 complex functions in postmitotic, adult somatic tissues of IIS mutants to enhance longevity. Reducing IIS function leads to the nuclear accumulation of the DAF-16/FOXO transcription factor, which extends lifespan by regulating downstream longevity genes. These CUL-1 complex genes act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO. Together, our findings describe a role for an important cellular pathway, the proteasomal pathway, in the genetic determination of lifespan." @default.
• W2047102030 created "2016-06-24" @default.
• W2047102030 creator A5053475144 @default.
• W2047102030 creator A5065514587 @default.
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• W2047102030 date "2007-04-03" @default.
• W2047102030 modified "2023-10-09" @default.
• W2047102030 title "Regulation of <i>Caenorhabditis elegans</i> lifespan by a proteasomal E3 ligase complex" @default.
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• W2047102030 doi "https://doi.org/10.1073/pnas.0700638104" @default.
• W2047102030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1851597" @default.
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• W2047102030 hasPublicationYear "2007" @default.
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