FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047116854> ?p ?o ?g. }

• W2047116854 endingPage "190" @default.
• W2047116854 startingPage "183" @default.
• W2047116854 abstract "Increased osteocyte apoptosis, as the result of estrogen deficiency, could play a role in the decrease of bone mass and bone strength seen in postmenopausal osteoporosis. We investigated whether treatment with raloxifene of postmenopausal women with osteoporosis affects osteocyte apoptosis. Transiliac bone biopsies were obtained from 26 osteoporotic women at baseline and after 2 years of treatment with placebo or raloxifene. Immunohistochemical detection of cleaved caspase-3 was performed on sections from nondecalcified bone biopsies to visualize apoptosis. In the trabecular bone total osteocytes, positively stained osteocytes and empty lacunae were counted and percent positive cells and percent empty lacunae determined. Statistical evaluation was performed by Wilcoxon's paired t-test and Spearman's rank correlations. There was no significant difference in percentage positive osteocytes between baseline and follow-up biopsies in both the placebo and the raloxifene groups. The percentage empty lacunae increased significantly in the placebo group (11.20 +/- 1.43 vs. 9.00 +/- 2.25, P = 0.014) but not in the raloxifene group. At baseline in both groups combined, there was a negative correlation between indices of bone remodeling and the percentage positive osteocytes (bone formation rate/bone volume r = -0.67, P = 0.001). We found no direct evidence for an effect of raloxifene treatment on osteocyte apoptosis, but small effects of raloxifene treatment cannot be excluded. The percent of apoptotic osteocytes was dependent on the level of bone remodeling in an individual." @default.
• W2047116854 created "2016-06-24" @default.
• W2047116854 creator A5001830310 @default.
• W2047116854 creator A5058475886 @default.
• W2047116854 creator A5060187265 @default.
• W2047116854 creator A5062035305 @default.
• W2047116854 creator A5073246714 @default.
• W2047116854 date "2007-08-04" @default.
• W2047116854 modified "2023-10-14" @default.
• W2047116854 title "Effect of Raloxifene Treatment on Osteocyte Apoptosis in Postmenopausal Women" @default.
• W2047116854 cites W1966391931 @default.
• W2047116854 cites W1967733058 @default.
• W2047116854 cites W1969945802 @default.
• W2047116854 cites W1972746242 @default.
• W2047116854 cites W1979821211 @default.
• W2047116854 cites W1986156740 @default.
• W2047116854 cites W1988648898 @default.
• W2047116854 cites W1989096197 @default.
• W2047116854 cites W1991243886 @default.
• W2047116854 cites W1992361419 @default.
• W2047116854 cites W2001046511 @default.
• W2047116854 cites W2001433517 @default.
• W2047116854 cites W2008698339 @default.
• W2047116854 cites W2020238012 @default.
• W2047116854 cites W2024609097 @default.
• W2047116854 cites W2035195447 @default.
• W2047116854 cites W2039223695 @default.
• W2047116854 cites W2040554717 @default.
• W2047116854 cites W2068014772 @default.
• W2047116854 cites W2074713038 @default.
• W2047116854 cites W2075164824 @default.
• W2047116854 cites W2085989796 @default.
• W2047116854 cites W2087378917 @default.
• W2047116854 cites W2087877947 @default.
• W2047116854 cites W2090640733 @default.
• W2047116854 cites W2110436488 @default.
• W2047116854 cites W2112629831 @default.
• W2047116854 cites W2146818843 @default.
• W2047116854 cites W2154012098 @default.
• W2047116854 cites W2164319357 @default.
• W2047116854 cites W2168587822 @default.
• W2047116854 cites W2170680219 @default.
• W2047116854 cites W2170750104 @default.
• W2047116854 cites W2172224570 @default.
• W2047116854 cites W2288760711 @default.
• W2047116854 cites W4233177219 @default.
• W2047116854 cites W4233274199 @default.
• W2047116854 cites W4243469444 @default.
• W2047116854 cites W4247239414 @default.
• W2047116854 cites W4248684452 @default.
• W2047116854 cites W4253903652 @default.
• W2047116854 doi "https://doi.org/10.1007/s00223-007-9050-0" @default.
• W2047116854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2039811" @default.
• W2047116854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17676256" @default.
• W2047116854 hasPublicationYear "2007" @default.
• W2047116854 type Work @default.
• W2047116854 sameAs 2047116854 @default.
• W2047116854 citedByCount "19" @default.
• W2047116854 countsByYear W20471168542012 @default.
• W2047116854 countsByYear W20471168542014 @default.
• W2047116854 countsByYear W20471168542015 @default.
• W2047116854 countsByYear W20471168542016 @default.
• W2047116854 countsByYear W20471168542019 @default.
• W2047116854 countsByYear W20471168542020 @default.
• W2047116854 countsByYear W20471168542022 @default.
• W2047116854 crossrefType "journal-article" @default.
• W2047116854 hasAuthorship W2047116854A5001830310 @default.
• W2047116854 hasAuthorship W2047116854A5058475886 @default.
• W2047116854 hasAuthorship W2047116854A5060187265 @default.
• W2047116854 hasAuthorship W2047116854A5062035305 @default.
• W2047116854 hasAuthorship W2047116854A5073246714 @default.
• W2047116854 hasBestOaLocation W20471168541 @default.
• W2047116854 hasConcept C121608353 @default.
• W2047116854 hasConcept C126322002 @default.
• W2047116854 hasConcept C126894567 @default.
• W2047116854 hasConcept C134018914 @default.
• W2047116854 hasConcept C142724271 @default.
• W2047116854 hasConcept C170033053 @default.
• W2047116854 hasConcept C185592680 @default.
• W2047116854 hasConcept C202751555 @default.
• W2047116854 hasConcept C204787440 @default.
• W2047116854 hasConcept C27081682 @default.
• W2047116854 hasConcept C2776541429 @default.
• W2047116854 hasConcept C2776594446 @default.
• W2047116854 hasConcept C2776886416 @default.
• W2047116854 hasConcept C2777083390 @default.
• W2047116854 hasConcept C2778260815 @default.
• W2047116854 hasConcept C2779889926 @default.
• W2047116854 hasConcept C2780973866 @default.
• W2047116854 hasConcept C530470458 @default.
• W2047116854 hasConcept C55493867 @default.
• W2047116854 hasConcept C71924100 @default.
• W2047116854 hasConcept C84606932 @default.
• W2047116854 hasConceptScore W2047116854C121608353 @default.
• W2047116854 hasConceptScore W2047116854C126322002 @default.
• W2047116854 hasConceptScore W2047116854C126894567 @default.
• W2047116854 hasConceptScore W2047116854C134018914 @default.
• W2047116854 hasConceptScore W2047116854C142724271 @default.

• next