FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047117908> ?p ?o ?g. }

• W2047117908 endingPage "6266" @default.
• W2047117908 startingPage "6257" @default.
• W2047117908 abstract "Previously, we reported that Akt inactivation determines the sensitivity of hepatocellular carcinoma (HCC) cells to bortezomib. In this study, we report that cancerous inhibitor of protein phosphatase 2A (CIP2A), a cellular inhibitor of protein phosphatase 2A (PP2A), mediates the apoptotic effect of bortezomib in HCC. Silencing PP2A by small interference RNA (siRNA) abolishes bortezomib-induced down-regulation of phospho-Akt and apoptosis. Bortezomib increases PP2A activity in sensitive HCC cells, including Sk-Hep1, Hep3B and Huh-7, but not in resistant PLC5 cells. Bortezomib down-regulates CIP2A in a dose- and time-dependent manner in all sensitive HCC cells, whereas no alterations in CIP2A were found in resistant PLC5 cells. Knockdown of CIP2A by siRNA restored bortezomib’s effects on apoptosis and PP2A activity in PLC5 cells. Moreover, over-expression of CIP2A up-regulated phospho-Akt and protected Sk-Hep1 cells from bortezomib-induced apoptosis. It is significant that, ectopic expression of CIP2A decreased Akt-related PP2A activity, whereas silencing CIP2A increased this activity, indicating that CIP2A negatively regulates Akt-related PP2A activity in HCC cells, furthermore, our in vivo data showed that bortezomib down-regulates CIP2A and up-regulates PP2A activity in Huh-7 tumors, but not in PLC5 tumors. In conclusion, inhibition of CIP2A determines the effects of bortezomib on apoptosis and PP2A-dependent Akt inactivation in HCC." @default.
• W2047117908 created "2016-06-24" @default.
• W2047117908 creator A5017953971 @default.
• W2047117908 creator A5021439059 @default.
• W2047117908 creator A5045281078 @default.
• W2047117908 creator A5049909942 @default.
• W2047117908 creator A5065759458 @default.
• W2047117908 creator A5069691392 @default.
• W2047117908 creator A5074615872 @default.
• W2047117908 creator A5089160687 @default.
• W2047117908 date "2010-08-23" @default.
• W2047117908 modified "2023-10-17" @default.
• W2047117908 title "CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells" @default.
• W2047117908 cites W1971837077 @default.
• W2047117908 cites W1981083415 @default.
• W2047117908 cites W1992366030 @default.
• W2047117908 cites W1999141617 @default.
• W2047117908 cites W2014847481 @default.
• W2047117908 cites W2017958579 @default.
• W2047117908 cites W2024991339 @default.
• W2047117908 cites W2027250628 @default.
• W2047117908 cites W2037657103 @default.
• W2047117908 cites W2071989867 @default.
• W2047117908 cites W2077247713 @default.
• W2047117908 cites W2079111811 @default.
• W2047117908 cites W2083459920 @default.
• W2047117908 cites W2095304369 @default.
• W2047117908 cites W2099878195 @default.
• W2047117908 cites W2111614147 @default.
• W2047117908 cites W2118559527 @default.
• W2047117908 cites W2121214953 @default.
• W2047117908 cites W2121398618 @default.
• W2047117908 cites W2150775371 @default.
• W2047117908 cites W2156118283 @default.
• W2047117908 cites W2166761147 @default.
• W2047117908 cites W4240253200 @default.
• W2047117908 doi "https://doi.org/10.1038/onc.2010.357" @default.
• W2047117908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20729919" @default.
• W2047117908 hasPublicationYear "2010" @default.
• W2047117908 type Work @default.
• W2047117908 sameAs 2047117908 @default.
• W2047117908 citedByCount "145" @default.
• W2047117908 countsByYear W20471179082012 @default.
• W2047117908 countsByYear W20471179082013 @default.
• W2047117908 countsByYear W20471179082014 @default.
• W2047117908 countsByYear W20471179082015 @default.
• W2047117908 countsByYear W20471179082016 @default.
• W2047117908 countsByYear W20471179082017 @default.
• W2047117908 countsByYear W20471179082018 @default.
• W2047117908 countsByYear W20471179082019 @default.
• W2047117908 countsByYear W20471179082020 @default.
• W2047117908 countsByYear W20471179082021 @default.
• W2047117908 countsByYear W20471179082022 @default.
• W2047117908 countsByYear W20471179082023 @default.
• W2047117908 crossrefType "journal-article" @default.
• W2047117908 hasAuthorship W2047117908A5017953971 @default.
• W2047117908 hasAuthorship W2047117908A5021439059 @default.
• W2047117908 hasAuthorship W2047117908A5045281078 @default.
• W2047117908 hasAuthorship W2047117908A5049909942 @default.
• W2047117908 hasAuthorship W2047117908A5065759458 @default.
• W2047117908 hasAuthorship W2047117908A5069691392 @default.
• W2047117908 hasAuthorship W2047117908A5074615872 @default.
• W2047117908 hasAuthorship W2047117908A5089160687 @default.
• W2047117908 hasBestOaLocation W20471179081 @default.
• W2047117908 hasConcept C104317684 @default.
• W2047117908 hasConcept C119056186 @default.
• W2047117908 hasConcept C11960822 @default.
• W2047117908 hasConcept C173396325 @default.
• W2047117908 hasConcept C178666793 @default.
• W2047117908 hasConcept C190283241 @default.
• W2047117908 hasConcept C203014093 @default.
• W2047117908 hasConcept C2776364478 @default.
• W2047117908 hasConcept C2777478702 @default.
• W2047117908 hasConcept C2778367456 @default.
• W2047117908 hasConcept C389152 @default.
• W2047117908 hasConcept C502942594 @default.
• W2047117908 hasConcept C55493867 @default.
• W2047117908 hasConcept C62112901 @default.
• W2047117908 hasConcept C75217442 @default.
• W2047117908 hasConcept C86803240 @default.
• W2047117908 hasConcept C95444343 @default.
• W2047117908 hasConceptScore W2047117908C104317684 @default.
• W2047117908 hasConceptScore W2047117908C119056186 @default.
• W2047117908 hasConceptScore W2047117908C11960822 @default.
• W2047117908 hasConceptScore W2047117908C173396325 @default.
• W2047117908 hasConceptScore W2047117908C178666793 @default.
• W2047117908 hasConceptScore W2047117908C190283241 @default.
• W2047117908 hasConceptScore W2047117908C203014093 @default.
• W2047117908 hasConceptScore W2047117908C2776364478 @default.
• W2047117908 hasConceptScore W2047117908C2777478702 @default.
• W2047117908 hasConceptScore W2047117908C2778367456 @default.
• W2047117908 hasConceptScore W2047117908C389152 @default.
• W2047117908 hasConceptScore W2047117908C502942594 @default.
• W2047117908 hasConceptScore W2047117908C55493867 @default.
• W2047117908 hasConceptScore W2047117908C62112901 @default.
• W2047117908 hasConceptScore W2047117908C75217442 @default.
• W2047117908 hasConceptScore W2047117908C86803240 @default.
• W2047117908 hasConceptScore W2047117908C95444343 @default.

• next