FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047130151> ?p ?o ?g. }

• W2047130151 endingPage "e75038" @default.
• W2047130151 startingPage "e75038" @default.
• W2047130151 abstract "Endocrine treatment is the most preferable systemic treatment in metastatic breast cancer patients that have had an estrogen receptor (ER) positive primary tumor or metastatic lesions, however, approximately 20% of these patients do not benefit from the therapy and demonstrate further metastatic progress. One reason for failure of endocrine therapy might be the heterogeneity of ER expression in tumor cells spreading from the primary tumor to distant sites which is reflected in detectable circulating tumor cells (CTCs).A sensitive and specific staining protocol for ER, keratin 8/18/19, CD45 was established. Peripheral blood from 35 metastatic breast cancer patients with ER-positive primary tumors was tested for the presence of CTCs. Keratin 8/18/19 and DAPI positive but CD45 negative cells were classified as CTCs and evaluated for ER staining. Subsequently, eight individual CTCs from four index patients (2 CTCs per patient) were isolated and underwent whole genome amplification and ESR1 gene mutation analysis.CTCs were detected in blood of 16 from 35 analyzed patients (46%), with a median of 3 CTCs/7.5 ml. In total, ER-negative CTCs were detected in 11/16 (69%) of the CTC positive cases, including blood samples with only ER-negative CTCs (19%) and samples with both ER-positive and ER-negative CTCs (50%). No correlation was found between the intensity and/or percentage of ER staining in the primary tumor with the number and ER status of CTCs of the same patient. ESR1 gene mutations were not found.CTCs frequently lack ER expression in metastatic breast cancer patients with ER-positive primary tumors and show a considerable intra-patient heterogeneity, which may reflect a mechanism to escape endocrine therapy. Provided single cell analysis did not support a role of ESR1 mutations in this process." @default.
• W2047130151 created "2016-06-24" @default.
• W2047130151 creator A5008875543 @default.
• W2047130151 creator A5042430625 @default.
• W2047130151 creator A5048105827 @default.
• W2047130151 creator A5061208293 @default.
• W2047130151 creator A5066113397 @default.
• W2047130151 creator A5088637879 @default.
• W2047130151 date "2013-09-18" @default.
• W2047130151 modified "2023-10-16" @default.
• W2047130151 title "Heterogeneity of Estrogen Receptor Expression in Circulating Tumor Cells from Metastatic Breast Cancer Patients" @default.
• W2047130151 cites W1520425169 @default.
• W2047130151 cites W1808104055 @default.
• W2047130151 cites W1961026612 @default.
• W2047130151 cites W1963601771 @default.
• W2047130151 cites W1964060051 @default.
• W2047130151 cites W1967937784 @default.
• W2047130151 cites W1981989535 @default.
• W2047130151 cites W2004412670 @default.
• W2047130151 cites W2005104372 @default.
• W2047130151 cites W2012597726 @default.
• W2047130151 cites W2013956549 @default.
• W2047130151 cites W2018579586 @default.
• W2047130151 cites W2023933362 @default.
• W2047130151 cites W2027390454 @default.
• W2047130151 cites W2043515643 @default.
• W2047130151 cites W2052631876 @default.
• W2047130151 cites W2055330058 @default.
• W2047130151 cites W2063140987 @default.
• W2047130151 cites W2065346432 @default.
• W2047130151 cites W2078904004 @default.
• W2047130151 cites W2088851260 @default.
• W2047130151 cites W2089595068 @default.
• W2047130151 cites W2097255042 @default.
• W2047130151 cites W2099335989 @default.
• W2047130151 cites W2100778529 @default.
• W2047130151 cites W2106271594 @default.
• W2047130151 cites W2111976640 @default.
• W2047130151 cites W2116388783 @default.
• W2047130151 cites W2117206813 @default.
• W2047130151 cites W2117357260 @default.
• W2047130151 cites W2121672045 @default.
• W2047130151 cites W2126970578 @default.
• W2047130151 cites W2128371229 @default.
• W2047130151 cites W2128571346 @default.
• W2047130151 cites W2137853125 @default.
• W2047130151 cites W2144396863 @default.
• W2047130151 cites W2148874508 @default.
• W2047130151 cites W2155399095 @default.
• W2047130151 cites W2155869675 @default.
• W2047130151 cites W2158210303 @default.
• W2047130151 cites W2158794266 @default.
• W2047130151 cites W2161661776 @default.
• W2047130151 cites W2161770015 @default.
• W2047130151 cites W2165999332 @default.
• W2047130151 cites W2166838053 @default.
• W2047130151 cites W2171288191 @default.
• W2047130151 cites W2171316676 @default.
• W2047130151 cites W4211225392 @default.
• W2047130151 doi "https://doi.org/10.1371/journal.pone.0075038" @default.
• W2047130151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3776726" @default.
• W2047130151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24058649" @default.
• W2047130151 hasPublicationYear "2013" @default.
• W2047130151 type Work @default.
• W2047130151 sameAs 2047130151 @default.
• W2047130151 citedByCount "116" @default.
• W2047130151 countsByYear W20471301512014 @default.
• W2047130151 countsByYear W20471301512015 @default.
• W2047130151 countsByYear W20471301512016 @default.
• W2047130151 countsByYear W20471301512017 @default.
• W2047130151 countsByYear W20471301512018 @default.
• W2047130151 countsByYear W20471301512019 @default.
• W2047130151 countsByYear W20471301512020 @default.
• W2047130151 countsByYear W20471301512021 @default.
• W2047130151 countsByYear W20471301512022 @default.
• W2047130151 countsByYear W20471301512023 @default.
• W2047130151 crossrefType "journal-article" @default.
• W2047130151 hasAuthorship W2047130151A5008875543 @default.
• W2047130151 hasAuthorship W2047130151A5042430625 @default.
• W2047130151 hasAuthorship W2047130151A5048105827 @default.
• W2047130151 hasAuthorship W2047130151A5061208293 @default.
• W2047130151 hasAuthorship W2047130151A5066113397 @default.
• W2047130151 hasAuthorship W2047130151A5088637879 @default.
• W2047130151 hasBestOaLocation W20471301511 @default.
• W2047130151 hasConcept C121608353 @default.
• W2047130151 hasConcept C126322002 @default.
• W2047130151 hasConcept C142724271 @default.
• W2047130151 hasConcept C143998085 @default.
• W2047130151 hasConcept C172313692 @default.
• W2047130151 hasConcept C2775930923 @default.
• W2047130151 hasConcept C2779013556 @default.
• W2047130151 hasConcept C2780283643 @default.
• W2047130151 hasConcept C502942594 @default.
• W2047130151 hasConcept C530470458 @default.
• W2047130151 hasConcept C61238886 @default.
• W2047130151 hasConcept C71924100 @default.
• W2047130151 hasConcept C84606932 @default.
• W2047130151 hasConceptScore W2047130151C121608353 @default.

• next