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- W2047138085 abstract "Gold nanoparticles (AuNPs) covalently bound to biomolecules, termed bioconjugates,1 are highly relevant for biological applications like drug targeting or bioimaging. Here, the net charge of the bioconjugate is one key parameter affecting biocompatibility and cell membrane interaction. However, when negatively charged AuNPs are conjugated to positively charged biomolecules, resulting charge compensation compromises the stability of the conjugates. In this work, laser-generated negatively charged AuNPs exhibiting a bare surface were used as a model and separately conjugated to cell penetrating peptides (CPPs) carrying different positive net charges. Occurring charge compensation leads to two regimes where stable bioconjugates are obtained on both sides of the bioconjugate’s isoelectric point. These regimes can be controlled by the peptide’s net charge. Generally, increasing the peptide’s net charges yields stable positively charged bioconjugates with decreased surface coverages. To demonstrate the compatib..." @default.
- W2047138085 created "2016-06-24" @default.
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- W2047138085 date "2014-05-01" @default.
- W2047138085 modified "2023-10-16" @default.
- W2047138085 title "Charge Balancing of Model Gold-Nanoparticle-Peptide Conjugates Controlled by the Peptide’s Net Charge and the Ligand to Nanoparticle Ratio" @default.
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- W2047138085 doi "https://doi.org/10.1021/jp501489t" @default.
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