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- W2047144129 endingPage "e963447" @default.
- W2047144129 startingPage "e963447" @default.
- W2047144129 abstract "The PI3K/AKT/mTOR signaling is important for cell proliferation, survival, and metabolism. Hyperactivation of this pathway is one of the most common signaling abnormalities observed in cancer and a substantial effort has recently been made to develop molecules targeting this signaling cascade. However, it is becoming evident that PI3K inhibitors used as single agents do not elicit dramatic or durable responses. Given the numerous mechanisms mediating intrinsic and acquired resistance to these agents, hypothesis-based combinatorial strategies are probably needed to fully exploit their antitumor activity. In the first part of this review, we briefly dissect the PI3K/AKT/mTOR axis and list the most advanced compounds targeting different nodes of this cascade. The second part focuses on what we believe to be the most promising rationale-based therapeutic combinations with PI3K/AKT/mTOR inhibitors in solid tumors, with special emphasis on breast cancer." @default.
- W2047144129 created "2016-06-24" @default.
- W2047144129 creator A5002819777 @default.
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- W2047144129 creator A5040175058 @default.
- W2047144129 creator A5041876892 @default.
- W2047144129 creator A5067395984 @default.
- W2047144129 creator A5077626457 @default.
- W2047144129 creator A5084753857 @default.
- W2047144129 date "2014-09-15" @default.
- W2047144129 modified "2023-09-27" @default.
- W2047144129 title "Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment" @default.
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