FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047151010> ?p ?o ?g. }

• W2047151010 endingPage "43" @default.
• W2047151010 startingPage "39" @default.
• W2047151010 abstract "The cyclin-dependent kinase (CDK) inhibitor p21 plays key roles in p53-dependent DNA-damage responses, i.e., cell cycle checkpoints, senescence, or apoptosis. p21 might also play a role in DNA repair. p21 foci arise at heavy-ion-irradiated DNA-double-strand break (DSB) sites, which are mainly repaired by nonhomologous DNA-end-joining (NHEJ). However, no mechanisms of p21 accumulation at double-strand break (DSB) sites have been clarified in detail. Recent works indicate that Ku70 and Ku80 are essential for the accumulation of other NHEJ core factors, e.g., DNA-PKcs, XRCC4 and XLF, and other DNA damage response factors, e.g., BRCA1. Here, we show that p21 foci arise at laser-irradiated sites in cells from various tissues from various species. The accumulation of EGFP-p21 was detected in not only normal cells, but also transformed or cancer cells. Our results also showed that EGFP-p21 accumulated rapidly at irradiated sites, and colocalized with the DSB marker γ-H2AX and with the DSB sensor protein Ku80. On the other hand, the accumulation occurred in Ku70-, Ku80-, or DNA-PKcs-deficient cell lines and in human papillomavirus 18-positive cells, whereas the p21 mutant without the PCNA-binding region (EGFP-p21(1–146)) failed to accumulate at the irradiated sites. These findings suggest that the accumulation of p21, but not functional p53 and the NHEJ core factors, is dependent on PCNA. These findings also suggest that the accumulation activity of p21 at DNA damaged sites is conserved among human and animal cells, and p21 is a useful tool as a detection marker of DNA damaged sites." @default.
• W2047151010 created "2016-06-24" @default.
• W2047151010 creator A5068455464 @default.
• W2047151010 creator A5068784411 @default.
• W2047151010 creator A5052193522 @default.
• W2047151010 date "2011-08-01" @default.
• W2047151010 modified "2023-10-14" @default.
• W2047151010 title "Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation" @default.
• W2047151010 cites W1515564094 @default.
• W2047151010 cites W1889579009 @default.
• W2047151010 cites W1985775217 @default.
• W2047151010 cites W1991055045 @default.
• W2047151010 cites W1995719245 @default.
• W2047151010 cites W1997326654 @default.
• W2047151010 cites W2001399958 @default.
• W2047151010 cites W2001819193 @default.
• W2047151010 cites W2007369689 @default.
• W2047151010 cites W2015265974 @default.
• W2047151010 cites W2025993893 @default.
• W2047151010 cites W2033339712 @default.
• W2047151010 cites W2033485618 @default.
• W2047151010 cites W2035196363 @default.
• W2047151010 cites W2050164541 @default.
• W2047151010 cites W2055888987 @default.
• W2047151010 cites W2058592969 @default.
• W2047151010 cites W2060420406 @default.
• W2047151010 cites W2060975368 @default.
• W2047151010 cites W2101096499 @default.
• W2047151010 cites W2105847906 @default.
• W2047151010 cites W2121619780 @default.
• W2047151010 cites W2135457707 @default.
• W2047151010 cites W2152365838 @default.
• W2047151010 cites W2158901114 @default.
• W2047151010 cites W2164900838 @default.
• W2047151010 cites W2166994117 @default.
• W2047151010 doi "https://doi.org/10.1016/j.bbrc.2011.07.032" @default.
• W2047151010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21787748" @default.
• W2047151010 hasPublicationYear "2011" @default.
• W2047151010 type Work @default.
• W2047151010 sameAs 2047151010 @default.
• W2047151010 citedByCount "38" @default.
• W2047151010 countsByYear W20471510102012 @default.
• W2047151010 countsByYear W20471510102013 @default.
• W2047151010 countsByYear W20471510102014 @default.
• W2047151010 countsByYear W20471510102015 @default.
• W2047151010 countsByYear W20471510102016 @default.
• W2047151010 countsByYear W20471510102017 @default.
• W2047151010 countsByYear W20471510102018 @default.
• W2047151010 countsByYear W20471510102019 @default.
• W2047151010 countsByYear W20471510102020 @default.
• W2047151010 countsByYear W20471510102021 @default.
• W2047151010 countsByYear W20471510102022 @default.
• W2047151010 crossrefType "journal-article" @default.
• W2047151010 hasAuthorship W2047151010A5052193522 @default.
• W2047151010 hasAuthorship W2047151010A5068455464 @default.
• W2047151010 hasAuthorship W2047151010A5068784411 @default.
• W2047151010 hasConcept C104317684 @default.
• W2047151010 hasConcept C104451858 @default.
• W2047151010 hasConcept C122917832 @default.
• W2047151010 hasConcept C134935766 @default.
• W2047151010 hasConcept C143425029 @default.
• W2047151010 hasConcept C145803527 @default.
• W2047151010 hasConcept C153911025 @default.
• W2047151010 hasConcept C193104389 @default.
• W2047151010 hasConcept C2780919815 @default.
• W2047151010 hasConcept C34688535 @default.
• W2047151010 hasConcept C54355233 @default.
• W2047151010 hasConcept C552990157 @default.
• W2047151010 hasConcept C86339819 @default.
• W2047151010 hasConcept C86803240 @default.
• W2047151010 hasConcept C94966510 @default.
• W2047151010 hasConcept C95444343 @default.
• W2047151010 hasConceptScore W2047151010C104317684 @default.
• W2047151010 hasConceptScore W2047151010C104451858 @default.
• W2047151010 hasConceptScore W2047151010C122917832 @default.
• W2047151010 hasConceptScore W2047151010C134935766 @default.
• W2047151010 hasConceptScore W2047151010C143425029 @default.
• W2047151010 hasConceptScore W2047151010C145803527 @default.
• W2047151010 hasConceptScore W2047151010C153911025 @default.
• W2047151010 hasConceptScore W2047151010C193104389 @default.
• W2047151010 hasConceptScore W2047151010C2780919815 @default.
• W2047151010 hasConceptScore W2047151010C34688535 @default.
• W2047151010 hasConceptScore W2047151010C54355233 @default.
• W2047151010 hasConceptScore W2047151010C552990157 @default.
• W2047151010 hasConceptScore W2047151010C86339819 @default.
• W2047151010 hasConceptScore W2047151010C86803240 @default.
• W2047151010 hasConceptScore W2047151010C94966510 @default.
• W2047151010 hasConceptScore W2047151010C95444343 @default.
• W2047151010 hasIssue "1" @default.
• W2047151010 hasLocation W20471510101 @default.
• W2047151010 hasLocation W20471510102 @default.
• W2047151010 hasOpenAccess W2047151010 @default.
• W2047151010 hasPrimaryLocation W20471510101 @default.
• W2047151010 hasRelatedWork W1873396772 @default.
• W2047151010 hasRelatedWork W2007919127 @default.
• W2047151010 hasRelatedWork W2025951531 @default.
• W2047151010 hasRelatedWork W2028803759 @default.
• W2047151010 hasRelatedWork W2047804529 @default.

• next