FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047156985> ?p ?o ?g. }

• W2047156985 endingPage "58" @default.
• W2047156985 startingPage "52" @default.
• W2047156985 abstract "Glucocorticoids have been the hallmark anti-inflammatory drug used to treat asthma. It has been shown that glucocorticoids ameliorate asthma by increasing numbers and activity of Tregs, in contrast recent data show that glucocorticoid might have an opposite effect on Treg cells from normal mice. Since Tregs are target cells that act on the resolution of asthma, the aim of this study was to elucidate the effect of glucocorticoid treatment on lung Tregs in mouse models of asthma. Allergen challenged mice were treated with either oral dexamethasone or nebulized budesonide. Broncoalveolar lavage and airway hyperresponsiveness were evaluated after allergenic challenge. Lung, thymic and lymph node cells were phenotyped on Treg through flow cytometry. Lung cytokine secretion was detected by ELISA. Although dexamethasone inhibited airway inflammation and hyperresponsiveness, improving resolution, we have found that both dexamethasone and budesonide induce a reduction of Treg numbers on lungs and lymphoid organs of allergen challenged mice. The reduction of lung Treg levels was independent of mice strain or type of allergen challenge. Our study also indicates that both glucocorticoids do not increase Treg activity through production of IL-10. Glucocorticoid systemic or localized treatment induced thymic atrophy. Taken together, our results demonstrate that glucocorticoids decrease Treg numbers and activity in different asthma mouse models, probably by reducing thymic production of T cells. Therefore, it is possible that glucocorticoids do not have beneficial effects on lung populations of Treg cells from asthmatic patients." @default.
• W2047156985 created "2016-06-24" @default.
• W2047156985 creator A5015299645 @default.
• W2047156985 creator A5022261651 @default.
• W2047156985 creator A5034013632 @default.
• W2047156985 creator A5066115409 @default.
• W2047156985 creator A5078799744 @default.
• W2047156985 creator A5085165329 @default.
• W2047156985 date "2015-01-01" @default.
• W2047156985 modified "2023-10-16" @default.
• W2047156985 title "Glucocorticoids decrease Treg cell numbers in lungs of allergic mice" @default.
• W2047156985 cites W1582822353 @default.
• W2047156985 cites W1595855248 @default.
• W2047156985 cites W1605768991 @default.
• W2047156985 cites W1849310380 @default.
• W2047156985 cites W1963731074 @default.
• W2047156985 cites W1967399138 @default.
• W2047156985 cites W1967460244 @default.
• W2047156985 cites W1967714707 @default.
• W2047156985 cites W1968330080 @default.
• W2047156985 cites W1968336687 @default.
• W2047156985 cites W1971074604 @default.
• W2047156985 cites W1974070858 @default.
• W2047156985 cites W1991600170 @default.
• W2047156985 cites W2002889055 @default.
• W2047156985 cites W2004334951 @default.
• W2047156985 cites W2005268742 @default.
• W2047156985 cites W2014306009 @default.
• W2047156985 cites W2017829703 @default.
• W2047156985 cites W2018892195 @default.
• W2047156985 cites W204439679 @default.
• W2047156985 cites W2044987484 @default.
• W2047156985 cites W2044999953 @default.
• W2047156985 cites W2050286381 @default.
• W2047156985 cites W2051913840 @default.
• W2047156985 cites W2055573557 @default.
• W2047156985 cites W2062498772 @default.
• W2047156985 cites W2072853625 @default.
• W2047156985 cites W2074388949 @default.
• W2047156985 cites W2079533675 @default.
• W2047156985 cites W2098698630 @default.
• W2047156985 cites W2102150869 @default.
• W2047156985 cites W2109561957 @default.
• W2047156985 cites W2112669319 @default.
• W2047156985 cites W2114295340 @default.
• W2047156985 cites W2114352556 @default.
• W2047156985 cites W2145972397 @default.
• W2047156985 cites W2146006208 @default.
• W2047156985 cites W2146036781 @default.
• W2047156985 cites W2146990900 @default.
• W2047156985 cites W2150547407 @default.
• W2047156985 cites W2151677607 @default.
• W2047156985 cites W2157954415 @default.
• W2047156985 cites W2170235243 @default.
• W2047156985 doi "https://doi.org/10.1016/j.ejphar.2014.11.034" @default.
• W2047156985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25499819" @default.
• W2047156985 hasPublicationYear "2015" @default.
• W2047156985 type Work @default.
• W2047156985 sameAs 2047156985 @default.
• W2047156985 citedByCount "33" @default.
• W2047156985 countsByYear W20471569852016 @default.
• W2047156985 countsByYear W20471569852017 @default.
• W2047156985 countsByYear W20471569852018 @default.
• W2047156985 countsByYear W20471569852019 @default.
• W2047156985 countsByYear W20471569852020 @default.
• W2047156985 countsByYear W20471569852021 @default.
• W2047156985 countsByYear W20471569852022 @default.
• W2047156985 countsByYear W20471569852023 @default.
• W2047156985 crossrefType "journal-article" @default.
• W2047156985 hasAuthorship W2047156985A5015299645 @default.
• W2047156985 hasAuthorship W2047156985A5022261651 @default.
• W2047156985 hasAuthorship W2047156985A5034013632 @default.
• W2047156985 hasAuthorship W2047156985A5066115409 @default.
• W2047156985 hasAuthorship W2047156985A5078799744 @default.
• W2047156985 hasAuthorship W2047156985A5085165329 @default.
• W2047156985 hasConcept C126322002 @default.
• W2047156985 hasConcept C134018914 @default.
• W2047156985 hasConcept C203014093 @default.
• W2047156985 hasConcept C2776042228 @default.
• W2047156985 hasConcept C2776136866 @default.
• W2047156985 hasConcept C2776914184 @default.
• W2047156985 hasConcept C2777714996 @default.
• W2047156985 hasConcept C2780401358 @default.
• W2047156985 hasConcept C2780841215 @default.
• W2047156985 hasConcept C71924100 @default.
• W2047156985 hasConceptScore W2047156985C126322002 @default.
• W2047156985 hasConceptScore W2047156985C134018914 @default.
• W2047156985 hasConceptScore W2047156985C203014093 @default.
• W2047156985 hasConceptScore W2047156985C2776042228 @default.
• W2047156985 hasConceptScore W2047156985C2776136866 @default.
• W2047156985 hasConceptScore W2047156985C2776914184 @default.
• W2047156985 hasConceptScore W2047156985C2777714996 @default.
• W2047156985 hasConceptScore W2047156985C2780401358 @default.
• W2047156985 hasConceptScore W2047156985C2780841215 @default.
• W2047156985 hasConceptScore W2047156985C71924100 @default.
• W2047156985 hasFunder F4320322025 @default.
• W2047156985 hasFunder F4320322749 @default.
• W2047156985 hasLocation W20471569851 @default.

• next