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• W2047157317 abstract "Twenty-three adult patients in complete remission (CR) from acute leukemia were investigated for the steady-state bone marrow (BM) CFU-C concentration and the cytochemical findings of neutrophils and monocytes. There was considerable variation in CFU-C concentrations among patients. Patients with abnormality high or low values tended to relapse earlier. Repeated assays revealed constant CFU-C values in individual long-term cases of remission (4 cases). One case of M4 (myelomonocytic) and the case of M5b (monocytic) leukemia revealed a complete lack of nonspecific esterase activity in CR monocytes as well as initial leukemic promonocytes; they also showed abnormally high or low concentrations of CFU-C and relapsed early. This finding suggests that hematopoiesis in CR bone marrow occurs from abnormal stem cells common to initial, acute leukemic clones in such cases." @default.
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• W2047157317 date "1985-01-01" @default.
• W2047157317 modified "2023-09-25" @default.
• W2047157317 title "CFU-C abnormalities and cytochemical defects in bone marrow of adult patients during remission of acute leukemia" @default.
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• W2047157317 doi "https://doi.org/10.1016/0145-2126(85)90141-9" @default.
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