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• W2047162021 abstract "Significance In several critically ill patients the homeostatic regulation of adrenocortical hormone secretion is impaired. Toll-like receptors (TLR) play a substantial role in HPA axis activation in the course of systemic inflammation. Here, using mice with conditional deletion of a crucial TLR adapter protein, MyD88, we investigated the role of systemic and local adrenal TLR signaling in the activation of adrenal glucocorticoid responses to stress and regulation of immune-adrenal crosstalk during systemic inflammatory response syndrome. Our results suggest that immune cells, rather than adrenal cells, are major regulators of the systemic and intra-adrenal inflammatory response to LPS. However, the full HPA axis activation in SIRS is not entirely dependent on systemic TLR signaling." @default.
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• W2047162021 date "2013-08-19" @default.
• W2047162021 modified "2023-10-18" @default.
• W2047162021 title "Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation" @default.
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• W2047162021 doi "https://doi.org/10.1073/pnas.1313945110" @default.
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