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• W2047166535 abstract "Accurate initiation of eukaryotic mRNA synthesis takes place as a result of the interplay between general transcription factors and RNA polymerase II. Activation of transcription from the basal level involves a number of promoter‐specific trans ‐acting factors which interact with cis elements in the promoter DNA. In this paper we have emphasized the importance of even those portions of the promoter stretch which do not have any identifiable binding sites for regulatory proteins. The length and structure of the DNA between cognate binding sites of trans ‐acting factors may interfere with the level of transcriptional activation. Depending upon the length of the intervening DNA we describe three cases of transcriptional activation. In addition, based on this classification we propose a new third domain, the other two being DNA binding and transcriptional activation domains, which is involved in bending the intervening DNA so that activation from a distance can take place successfully." @default.
• W2047166535 created "2016-06-24" @default.
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• W2047166535 date "1992-08-03" @default.
• W2047166535 modified "2023-09-25" @default.
• W2047166535 title "DNA intervention in transcriptional activation" @default.
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• W2047166535 doi "https://doi.org/10.1016/0014-5793(92)80687-c" @default.
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