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- W2047176456 abstract "A causal relationship has been suggested between the altered electrical cortical activity and the increases in both cortical metabolism and blood flow which follow experimental reticulocortical activation. To further study this hypothesis, cortical O2 consumption, NADH fluorescence, and blood flow were monitored simultaneously with aortic blood pressure and ECoG after the electrical stimulation of the pontomesencephalic reticular formation (MRF) in anesthetized cats. Reversible increases in blood pressure, cortical blood flow, and O2 consumption, and decreases in NADH fluorescence were induced by MRF stimulation. All these changes were linearly related to each other as a function of stimulus intensity; they were often but not always associated with an increase in the ECoG frequency. MRF stimulation after ganglionic suppression with hexamethonium chloride revealed a dissociation of the resulting changes in the ECoG from the changes in cortical blood flow and metabolism. In addition, pharmacologically induced acute elevations of blood pressure caused changes in the experimental parameters similar to those which followed MRF stimulation but without a significant effect on the ECoG. We conclude that (i) acute increases in cortical blood flow and oxidative metabolism after electrical MRF stimulation may be more related to the simultaneous elevations of blood pressure than to changes in the ECoG; and (ii) an acute increase in cortical blood flow may by itself stimulate cortical oxidative metabolism in the anesthetized cat." @default.
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- W2047176456 date "1981-03-01" @default.
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- W2047176456 title "Effects of brain stem stimulation on cortical NADH fluorescence, blood flow, and O2 consumption in the cat" @default.
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- W2047176456 doi "https://doi.org/10.1016/0014-4886(81)90034-0" @default.
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