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• W2047177703 abstract "Accumulating evidence suggests that L-dihydroxyphenylalanine (L-DOPA) has neurotransmitter-like and/or neuromodulatory properties in the CNS. Such evidence is based on a wide range of findings including the existence of specific L-DOPAergic neurons in several regions of the CNS, neurotransmitter-like characteristics and specific pharmacological effects. This review attempts to outline the main evidence for this conception and to relate such findings to L-DOPA treatment effects in Parkinson's disease. In this context L-DOPA in itself has been shown to potentiate D2 receptor-mediated effects, inhibit acetylcholine release and increase the release of L-glutamate, neuropharmacological effects which can be linked to treatment side-effects in advanced Parkinson's disease. It is suggested that supersensitive L-DOPA-mediated effects contribute to the pathogenesis underlying L-DOPA-induced motor complications in advanced Parkinson's disease. However, since specific L-DOPA receptors have yet to be identified, the assessment of the relative importance of L-DOPA-mediated effects in this clinical context must be regarded as incomplete." @default.
• W2047177703 created "2016-06-24" @default.
• W2047177703 creator A5014624169 @default.
• W2047177703 date "1997-01-01" @default.
• W2047177703 modified "2023-09-24" @default.
• W2047177703 title "The Neuroregulatory Properties of L-DOPA. A Review of the Evidence and Potential Role in the Treatment of Parkinson's Disease" @default.
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• W2047177703 doi "https://doi.org/10.1515/revneuro.1997.8.3-4.195" @default.
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