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• W2047188045 abstract "Abstract: The effects of aluminium on inositol phosphate formation were examined in murine neuroblastoma cells labelled with [3H]-myo-inositol. In aluminium-pretreated cells, the bradykinin-triggered inositol triphosphate, IP3, release and the change in intracellular [Ca2+] were appreciably less compared with the control group. Stimulating digitonin-permeabilized cells with non-hydrolyzable guanosine 5′-[gamma-thio]-triphosphate, GTP[S], inositol phosphate formation decreased in the presence of aluminium. A primary target of aluminium toxicity may reside on the guanine nucleotide-binding protein(Gp)/phospholipase C system, at a site different from that of the GTP[S] binding site." @default.
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• W2047188045 date "1992-10-01" @default.
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• W2047188045 title "Aluminium Interferes with Signal Transduction in Neuroblastoma Cells" @default.
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• W2047188045 doi "https://doi.org/10.1111/j.1600-0773.1992.tb00990.x" @default.
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