Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047188977> ?p ?o ?g. }
- W2047188977 endingPage "542" @default.
- W2047188977 startingPage "530" @default.
- W2047188977 abstract "Inbred mouse strain comparisons are an important aspect of pharmacogenetic research, especially in strains known to differ in regard to specific neurotransmitter systems. DBA/2 mice differ from C57BL/6 mice in terms of both functional and anatomical characteristics of dopamine systems. Given the importance of D2 antagonism in the action of antipsychotic drugs and in theories regarding schizophrenia (i.e. the dopamine hypothesis), this study compared the discriminative stimulus properties of the atypical antipsychotic drug clozapine (CLZ) in C57BL/6 and DBA/2 inbred mice. DBA/2 and C57BL/6 mice were trained to discriminate 2.5 mg/kg of CLZ from vehicle in a two-lever drug discrimination procedure and tested with a variety of antipsychotic drugs and selective ligands. Both strains of mice readily acquired the CLZ discrimination. The atypical antipsychotic drugs olanzapine and risperidone fully substituted for CLZ in both DBA/2 and C57BL/6 mice, but ziprasidone fully substituted only in the C57BL/6 mice. The typical antipsychotic drug haloperidol produced partial substitution for CLZ in the DBA/2 mice, and the dopamine agonist amphetamine required a higher dose to reduce response rates significantly in DBA/2 mice as compared with C57BL/6 mice. Antagonism of serotonergic (5-HT2A/2B/2C) receptors with ritanserin and alpha1-adrenergic receptors with prazosin engendered CLZ-appropriate responding only in the C57BL/6 mice. Thus, while serotonergic and alpha-adrenergic antagonism were shown to be important for CLZ's discriminative cue in C57BL/6 mice, none of the selective ligands produced CLZ-appropriate responding in DBA/2 mice. Differences in dopamine-mediated functions between the two strains of mice may explain some of the findings in this study." @default.
- W2047188977 created "2016-06-24" @default.
- W2047188977 creator A5026068886 @default.
- W2047188977 creator A5038492593 @default.
- W2047188977 creator A5040251023 @default.
- W2047188977 creator A5044488149 @default.
- W2047188977 creator A5067058663 @default.
- W2047188977 date "2008-09-01" @default.
- W2047188977 modified "2023-10-14" @default.
- W2047188977 title "A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred mice" @default.
- W2047188977 cites W1963673462 @default.
- W2047188977 cites W1967034969 @default.
- W2047188977 cites W1968081848 @default.
- W2047188977 cites W1968757097 @default.
- W2047188977 cites W1968937189 @default.
- W2047188977 cites W1969487195 @default.
- W2047188977 cites W1972398850 @default.
- W2047188977 cites W1973757586 @default.
- W2047188977 cites W1973850878 @default.
- W2047188977 cites W1974196136 @default.
- W2047188977 cites W1974780218 @default.
- W2047188977 cites W1977419021 @default.
- W2047188977 cites W1979700184 @default.
- W2047188977 cites W1983992895 @default.
- W2047188977 cites W2004320819 @default.
- W2047188977 cites W2005797832 @default.
- W2047188977 cites W20121689 @default.
- W2047188977 cites W2016628671 @default.
- W2047188977 cites W2025535749 @default.
- W2047188977 cites W2027557269 @default.
- W2047188977 cites W2036918545 @default.
- W2047188977 cites W2037526863 @default.
- W2047188977 cites W2042631675 @default.
- W2047188977 cites W2046067138 @default.
- W2047188977 cites W2047120243 @default.
- W2047188977 cites W2049122418 @default.
- W2047188977 cites W2051238722 @default.
- W2047188977 cites W2051653917 @default.
- W2047188977 cites W2053754882 @default.
- W2047188977 cites W2054776589 @default.
- W2047188977 cites W2067573080 @default.
- W2047188977 cites W2069079035 @default.
- W2047188977 cites W2069507134 @default.
- W2047188977 cites W2072501211 @default.
- W2047188977 cites W2074668691 @default.
- W2047188977 cites W2075712526 @default.
- W2047188977 cites W2076723097 @default.
- W2047188977 cites W2079361198 @default.
- W2047188977 cites W2081181656 @default.
- W2047188977 cites W2085295082 @default.
- W2047188977 cites W2085360366 @default.
- W2047188977 cites W2090415417 @default.
- W2047188977 cites W2095213614 @default.
- W2047188977 cites W2103205725 @default.
- W2047188977 cites W2117875235 @default.
- W2047188977 cites W2127905906 @default.
- W2047188977 cites W2128578499 @default.
- W2047188977 cites W4232804908 @default.
- W2047188977 cites W4237036051 @default.
- W2047188977 cites W66293174 @default.
- W2047188977 doi "https://doi.org/10.1097/fbp.0b013e32830cd84e" @default.
- W2047188977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18690107" @default.
- W2047188977 hasPublicationYear "2008" @default.
- W2047188977 type Work @default.
- W2047188977 sameAs 2047188977 @default.
- W2047188977 citedByCount "15" @default.
- W2047188977 countsByYear W20471889772014 @default.
- W2047188977 countsByYear W20471889772016 @default.
- W2047188977 countsByYear W20471889772017 @default.
- W2047188977 countsByYear W20471889772019 @default.
- W2047188977 crossrefType "journal-article" @default.
- W2047188977 hasAuthorship W2047188977A5026068886 @default.
- W2047188977 hasAuthorship W2047188977A5038492593 @default.
- W2047188977 hasAuthorship W2047188977A5040251023 @default.
- W2047188977 hasAuthorship W2047188977A5044488149 @default.
- W2047188977 hasAuthorship W2047188977A5067058663 @default.
- W2047188977 hasConcept C118552586 @default.
- W2047188977 hasConcept C126322002 @default.
- W2047188977 hasConcept C15744967 @default.
- W2047188977 hasConcept C170493617 @default.
- W2047188977 hasConcept C2775864247 @default.
- W2047188977 hasConcept C2775870346 @default.
- W2047188977 hasConcept C2776412080 @default.
- W2047188977 hasConcept C2776619155 @default.
- W2047188977 hasConcept C2776885963 @default.
- W2047188977 hasConcept C2776921671 @default.
- W2047188977 hasConcept C2777450907 @default.
- W2047188977 hasConcept C2778938600 @default.
- W2047188977 hasConcept C2780494398 @default.
- W2047188977 hasConcept C2780648677 @default.
- W2047188977 hasConcept C2780864610 @default.
- W2047188977 hasConcept C2780948584 @default.
- W2047188977 hasConcept C2910202354 @default.
- W2047188977 hasConcept C37000724 @default.
- W2047188977 hasConcept C44208683 @default.
- W2047188977 hasConcept C513476851 @default.
- W2047188977 hasConcept C71924100 @default.
- W2047188977 hasConcept C98274493 @default.