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• W2047202466 endingPage "942" @default.
• W2047202466 startingPage "935" @default.
• W2047202466 abstract "Activated T-lymphocytes may regulate the eosinophilic inflammation of bronchial asthma. In the present study, we investigated T cell activation and eosinophilia in blood and bronchoalveolar lavage (BAL) in 17 patients with asthma not receiving steroid treatment. Compared to normal individuals, BAL from patients with asthma contained significantly increased numbers of both lymphocytes and eosinophils (EOSs). The lymphocytosis consisted of increased numbers of both CD4+ and CD8+ T cells, and these T cell populations expressed elevated levels of T cell activation markers (interleukin-2 receptor [CD25], HLA-DR, and very late activation antigen 1). Close correlation was found between numbers of BAL CD4+ IL-2R+ T cells and numbers of EOSs. Moreover, the numbers of activated T cells and EOSs were related to the severity of asthma as measured by impairment of FEV1 and increased methacholine bronchial responsiveness. We demonstrate in both blood and BAL a close correlation between T cell activation, eosinophilia, and severity of asthma, suggesting that recruitment and activation of lymphocytes and EOSs are fundamental to the pathogenesis of bronchial asthma." @default.
• W2047202466 created "2016-06-24" @default.
• W2047202466 creator A5043208437 @default.
• W2047202466 creator A5048997830 @default.
• W2047202466 creator A5061070045 @default.
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• W2047202466 date "1991-12-01" @default.
• W2047202466 modified "2023-10-17" @default.
• W2047202466 title "Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity" @default.
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• W2047202466 doi "https://doi.org/10.1016/0091-6749(91)90251-i" @default.
• W2047202466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1744364" @default.
• W2047202466 hasPublicationYear "1991" @default.
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