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- W2047206060 endingPage "525" @default.
- W2047206060 startingPage "499" @default.
- W2047206060 abstract "Drug-protein binding is an important process in determining the activity and fate of a pharmaceutical agent once it has entered the body. This review examines various chromatographic and electrophoretic methods that have been developed to study such interactions. An overview of each technique is presented along with a discussion of its strengths, weaknesses and potential applications. Formats that are discussed include the use of both soluble and immobilized drugs or proteins, and approaches based on zonal elution, frontal analysis or vacancy peak measurements. Furthermore, examples are provided that illustrate the use of these methods in determining the overall extent of drug-protein binding, in examining the displacement of a drug by other agents and in measuring the equilibrium or rate constants for drug-protein interactions. Examples are also given demonstrating how the same methods, particularly when used in high-performance liquid chromatography or capillary electrophoresis systems, can be employed as rapid screening tools for investigating the binding of different forms of a chiral drug to a protein or the binding of different proteins and peptides to a given pharmaceutical agent." @default.
- W2047206060 created "2016-06-24" @default.
- W2047206060 creator A5020162521 @default.
- W2047206060 creator A5065944896 @default.
- W2047206060 date "1997-10-01" @default.
- W2047206060 modified "2023-10-10" @default.
- W2047206060 title "Recent advances in chromatographic and electrophoretic methods for the study of drug-protein interactions" @default.
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