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- W2047212994 abstract "The title compounds, C16H15BrN3O3+·Cl−·CH4O (WHI–P154) and C16H16N3O3+·Cl− (WHI–P180), are potent inhibitors [WHI–P154 with IC50 = 5.6 µM and WHI–P180 with IC50 = 4.0 µM for epidermal growth factor receptor (EGFR) kinase inhibition] of the EGFR tyrosine kinase as well as Janus Kinase 3. The molecular structures of these compounds are very similar except for the dihedral angle between the anilino and quinazoline moieties which is 1.10 (5)° for WHI–P154, and 45.66 (6) and 25.29 (7)° for the two molecules of WHI–P180 in the asymmetric unit. The nitrogen at the N3 position is protonated in both structures and participates in hydrogen bonding with the chlorine anions." @default.
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- W2047212994 date "2001-01-15" @default.
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- W2047212994 title "4-[(3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate and 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride" @default.
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- W2047212994 doi "https://doi.org/10.1107/s0108270100013561" @default.
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