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• W2047222236 abstract "Abstract Hirschsprung's disease ( HSCR ) is a rare congenital disease caused by impaired proliferation and migration of neural crest cells. We investigated changes in expression of micro RNA s (mi RNA s) and the genes they regulate in tissues of patients with HSCR . Quantitative real‐time PCR and immunoblot analyses were used to measure levels of mi RNA , mRNA s, and proteins in colon tissues from 69 patients with HSCR and 49 individuals without HSCR (controls). Direct interactions between mi RNA s and specific mRNA s were indentified in vitro , while the function role of miR‐218‐1 was investigated by using miR‐218 transgenic mice. An increased level of miR‐218‐1 correlated with increased levels of SLIT 2 and decreased levels of RET and PLAG 1 mRNA and protein. The reductions in RET and PLAG 1 by miR‐218‐1 reduced proliferation and migration of SH ‐SY5Y cells. Overexpression of the secreted form of SLIT 2 inhibited cell migration via binding to its receptor ROBO 1 . Bowel tissues from miR‐218‐1 transgenic mice had nerve fibre hyperplasia and reduced numbers of gangliocytes, compared with wild‐type mice. Altered miR‐218‐1 regulation of SLIT2, RET and PLAG1 might be involved in the pathogenesis of HSCR ." @default.
• W2047222236 created "2016-06-24" @default.
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• W2047222236 date "2015-03-19" @default.
• W2047222236 modified "2023-10-17" @default.
• W2047222236 title "<scp>SLIT</scp>2/<scp>ROBO</scp>1‐miR‐218‐1‐<scp>RET</scp>/<scp>PLAG</scp>1: a new disease pathway involved in<scp>H</scp>irschsprung's disease" @default.
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• W2047222236 doi "https://doi.org/10.1111/jcmm.12454" @default.
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