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• W2047229352 abstract "Single-voxel magnetic resonance spectroscopy measurements of N-acetyl aspartate, choline, and creatine (Cr) are affected in patients with human immunodeficiency virus (HIV) and neurocognitive impairment. However, these metabolic markers are often normalized in affected central nervous system regions, such as the lenticular nuclei, after initiation of highly active antiretroviral therapy (HAART).To examine whether lactate (Lac), a marker of inflammation and anaerobic glycolysis, and lipid, an indicator of cell membrane turnover resulting from oxidative stress, could serve as surrogate biomarkers within the lenticular nuclei of HIV-positive patients with different degrees of neurocognitive impairment.Three-tesla 2-dimensional-chemical shift imaging magnetic resonance spectroscopy at echo times of 30 milliseconds and 135 milliseconds was performed in voxels overlapping the lenticular nuclei of seronegative controls and a spectrum of HIV-positive patients (neurocognitively normal, mildly impaired, or moderately to severely impaired).University of Pennsylvania, Philadelphia.Ten seronegative controls and 45 HIV-positive patients with different degrees of neurocognitive impairment (15 neurocognitively normal patients, 12 mildly impaired patients, and 18 moderately to severely impaired patients).In vivo 2-dimensional-chemical shift imaging magnetic resonance spectroscopy analysis of N-acetyl aspartate:Cr, choline:Cr, Lac:Cr, and (lipid + Lac):Cr ratios among the various groups. In addition, the effect of the degree of HAART central nervous system penetration (high vs low) on these ratios was studied.No significant lenticular nuclei atrophy was detected with volumes similar across all of the groups. Both N-acetyl aspartate:Cr and choline:Cr ratios were similar across all of the groups at either echo time. In contrast, the Lac:Cr ratio was significantly greater in HIV-positive patients with moderate to severe impairment compared with seronegative controls. The (lipid + Lac):Cr ratio was significantly elevated within each HIV-positive subgroup compared with seronegative controls. Within HIV-positive patients receiving HAART, the degree of central nervous system penetration (high vs low) did not affect metabolic ratios.As seen with 2-dimensional-chemical shift imaging magnetic resonance spectroscopy, HIV induces inflammation and oxidative stress in HIV-positive patients despite HAART. Lipid and Lac are more sensitive inflammatory biomarkers that may be used to differentiate HIV-positive subgroups. However, no significant difference in efficacy, as measured by metabolic ratios, exists for high- vs low-central nervous system-penetrating HAART." @default.
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• W2047229352 date "2007-09-01" @default.
• W2047229352 modified "2023-09-25" @default.
• W2047229352 title "Detection of Human Immunodeficiency Virus–Induced Inflammation and Oxidative Stress in Lenticular Nuclei With Magnetic Resonance Spectroscopy Despite Antiretroviral Therapy" @default.
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• W2047229352 cites W1537714951 @default.
• W2047229352 cites W1906511061 @default.
• W2047229352 cites W1969632109 @default.
• W2047229352 cites W1972529050 @default.
• W2047229352 cites W1973653978 @default.
• W2047229352 cites W1974060304 @default.
• W2047229352 cites W1985210561 @default.
• W2047229352 cites W1989161735 @default.
• W2047229352 cites W2005807968 @default.
• W2047229352 cites W2009156709 @default.
• W2047229352 cites W2011610626 @default.
• W2047229352 cites W2013952531 @default.
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• W2047229352 cites W2019425059 @default.
• W2047229352 cites W2026268030 @default.
• W2047229352 cites W2027439115 @default.
• W2047229352 cites W2027580727 @default.
• W2047229352 cites W2027876153 @default.
• W2047229352 cites W2043281805 @default.
• W2047229352 cites W2045852759 @default.
• W2047229352 cites W2047384740 @default.
• W2047229352 cites W2049689895 @default.
• W2047229352 cites W2050660837 @default.
• W2047229352 cites W2051079006 @default.
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• W2047229352 cites W2058214611 @default.
• W2047229352 cites W2060006351 @default.
• W2047229352 cites W2060227312 @default.
• W2047229352 cites W2064192790 @default.
• W2047229352 cites W2064848158 @default.
• W2047229352 cites W2067478652 @default.
• W2047229352 cites W2069042370 @default.
• W2047229352 cites W2069166243 @default.
• W2047229352 cites W2084689734 @default.
• W2047229352 cites W2086934910 @default.
• W2047229352 cites W2087426245 @default.
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• W2047229352 doi "https://doi.org/10.1001/archneur.64.9.noc60125" @default.
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