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• W2047232012 abstract "0 d hysiological PTEN substrate is the lipidic second messener phosphatidylinositol-3,4,5-trisphosphate (PIP3). Thus, TEN reverts the phosphoinositide-3-kinases (PI3K) phoshorilation of phosphatidylinositol-4,5-bisphosphate (PIP2) o PIP3. As PIP3 activates the serine–threonine kinase Akt, hich is involved in anti-apoptosis, proliferation and oncoenesis, its dephosphorylation by PTEN negatively regulates umorigenesis. Mutations in the PTEN gene in human can ead to sporadic cancers (e.g., glioblastoma, endometrial and rostatic cancers) or to hereditary disorders characterized by ultiple hamartomas and increased risk of cancers (Cowden isease, Bannayan-Zonana syndrome and Lhermitte-Duclos isease). PTEN expression is also associated with neuronal ifferentiation [4,5] and G1 phase cell cycle arrest in cell ultures [6,7]. Dimethylsulfoxide (DMSO; (CH3)2SO) is also known to cell differentiating agent, reactive oxygen species scavenger, intercellular electrical uncoupler, LDL-derived cholesterol intracellular mobilization agent, G-actin in vitro modulator, cryoprotectant, remover of cell components on electron microscopy sample preparation, antidote to the extravasation of vesicant anticancer agents, topical analgesic, or on the treatment of Alzheimer’s disease, skeletal muscle disorders, pulmonary amyloidosis, interstitial cystitis and schizophrenia. Looking into all the aspects indicated in these works, it could easily be noticed that most of the researchers working with DMSO (or studying one of its specific effects) are unaware of the results of other groups working with the same molecule in another subject. This usual absence of a global insight of the subject often precludes the reaching of conclusions, leading also to erroneous interpretation of evidences, motivated by the experimental artifacts induced by dimethylsulfoxide. We rrests the cell cycle of several cell lines at the G1 phase (e.g., 8,9]). This fact raised the possibility of “the expression of TEN may be regulated by DMSO”, which was the core idea or the article by Lee et al. published in this issue of Leukemia believe that an increased awareness of the multidisciplinary utilization of this molecule in several research fields can be the best way to avoid or minimize these problems. The article by Lee et al. [10] reflects this desirable inc t p n h a s a ( ( esearch [10]. DMSO is a highly polar molecule with two apolar methyl roups, making it soluble both in aqueous and in organic meia. It is one of the most common solvents for the in vivo dministration of several water insoluble substances. As decribed by us in a recent work [11], despite being thoroughly" @default.
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• W2047232012 date "2005-04-01" @default.
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• W2047232012 title "PTEN “meets” DMSO" @default.
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• W2047232012 doi "https://doi.org/10.1016/j.leukres.2004.09.009" @default.
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