FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047236475> ?p ?o ?g. }

• W2047236475 endingPage "48" @default.
• W2047236475 startingPage "43" @default.
• W2047236475 abstract "Previous studies have demonstrated that tumor necrosis factor-alpha (TNF-α) in the red nucleus (RN) plays a facilitated role in the development of neuropathic pain. Here, the protein levels and roles of two different TNF receptors, p55 type 1 (TNFR1) and p75 type 2 (TNFR2), in the RN of rats with spared nerve injury (SNI) were investigated. Immunohistochemistry demonstrated that both TNFR1 and TNFR2 were significantly increased in the RN of rats with SNI compared with sham-operated and normal rats. The up-regulation of TNFR1 occurred at two weeks after SNI, while TNFR2 had markedly increased already at one week and began to decrease at two weeks after SNI. Microinjection of different doses (500, 250 and 100 ng) of anti-TNFR1 antibody (anti-TNFR1-Ab) or anti-TNFR2-Ab into the RN contralateral to the nerve injury side dose-dependently increased the paw withdrawal threshold of rats, as assessed using von Frey filaments. The analgesic effects produced by anti-TNFR1-Ab at one week and two weeks after SNI did not show significant difference. However, the analgesic effect produced by anti-TNFR2-Ab at two weeks after SNI was significantly lower and shorter than that produced at one week after SNI. Combined injection of anti-TNFR1-Ab and anti-TNFR2-Ab (500 ng for each antibody) into the RN generated a relatively faster and longer analgesic effect compared with single using of anti-TNFR1-Ab or anti-TNFR2-Ab. These results support that TNF-α in the RN plays a crucial role in regulating neuropathic pain, and suggest that the algesic effect of TNF-α is transmitted through both TNFR1 and TNFR2. TNFR1 has equally important role in the early development and later maintenance of neuropathic pain, while TNFR2 is more inclined to play a role in the early development of neuropathic pain." @default.
• W2047236475 created "2016-06-24" @default.
• W2047236475 creator A5004231157 @default.
• W2047236475 creator A5012392316 @default.
• W2047236475 creator A5046779901 @default.
• W2047236475 creator A5052441498 @default.
• W2047236475 creator A5062534632 @default.
• W2047236475 creator A5064056187 @default.
• W2047236475 date "2014-05-01" @default.
• W2047236475 modified "2023-09-27" @default.
• W2047236475 title "Distinct role of tumor necrosis factor receptor subtypes 1 and 2 in the red nucleus in the development of neuropathic pain" @default.
• W2047236475 cites W1965357024 @default.
• W2047236475 cites W1967358544 @default.
• W2047236475 cites W1968008199 @default.
• W2047236475 cites W1972592953 @default.
• W2047236475 cites W1979797122 @default.
• W2047236475 cites W1981014302 @default.
• W2047236475 cites W1988209540 @default.
• W2047236475 cites W1988855325 @default.
• W2047236475 cites W2003839387 @default.
• W2047236475 cites W2004211940 @default.
• W2047236475 cites W2022051828 @default.
• W2047236475 cites W2029227926 @default.
• W2047236475 cites W2039089996 @default.
• W2047236475 cites W2040443501 @default.
• W2047236475 cites W2044561802 @default.
• W2047236475 cites W2051408637 @default.
• W2047236475 cites W2055341552 @default.
• W2047236475 cites W2055353542 @default.
• W2047236475 cites W2057674925 @default.
• W2047236475 cites W2065173955 @default.
• W2047236475 cites W2069132744 @default.
• W2047236475 cites W2072153436 @default.
• W2047236475 cites W2087454739 @default.
• W2047236475 cites W2121082697 @default.
• W2047236475 cites W2121564080 @default.
• W2047236475 cites W2130330606 @default.
• W2047236475 cites W2172201406 @default.
• W2047236475 doi "https://doi.org/10.1016/j.neulet.2014.03.048" @default.
• W2047236475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24686175" @default.
• W2047236475 hasPublicationYear "2014" @default.
• W2047236475 type Work @default.
• W2047236475 sameAs 2047236475 @default.
• W2047236475 citedByCount "11" @default.
• W2047236475 countsByYear W20472364752014 @default.
• W2047236475 countsByYear W20472364752015 @default.
• W2047236475 countsByYear W20472364752016 @default.
• W2047236475 countsByYear W20472364752017 @default.
• W2047236475 countsByYear W20472364752019 @default.
• W2047236475 countsByYear W20472364752020 @default.
• W2047236475 countsByYear W20472364752021 @default.
• W2047236475 crossrefType "journal-article" @default.
• W2047236475 hasAuthorship W2047236475A5004231157 @default.
• W2047236475 hasAuthorship W2047236475A5012392316 @default.
• W2047236475 hasAuthorship W2047236475A5046779901 @default.
• W2047236475 hasAuthorship W2047236475A5052441498 @default.
• W2047236475 hasAuthorship W2047236475A5062534632 @default.
• W2047236475 hasAuthorship W2047236475A5064056187 @default.
• W2047236475 hasConcept C126322002 @default.
• W2047236475 hasConcept C134018914 @default.
• W2047236475 hasConcept C16993767 @default.
• W2047236475 hasConcept C170493617 @default.
• W2047236475 hasConcept C17991360 @default.
• W2047236475 hasConcept C185592680 @default.
• W2047236475 hasConcept C204232928 @default.
• W2047236475 hasConcept C2775991916 @default.
• W2047236475 hasConcept C2777107010 @default.
• W2047236475 hasConcept C2779708716 @default.
• W2047236475 hasConcept C2780820201 @default.
• W2047236475 hasConcept C3673659 @default.
• W2047236475 hasConcept C42219234 @default.
• W2047236475 hasConcept C55493867 @default.
• W2047236475 hasConcept C62525196 @default.
• W2047236475 hasConcept C71924100 @default.
• W2047236475 hasConcept C90149880 @default.
• W2047236475 hasConcept C93880895 @default.
• W2047236475 hasConcept C94412978 @default.
• W2047236475 hasConcept C98274493 @default.
• W2047236475 hasConceptScore W2047236475C126322002 @default.
• W2047236475 hasConceptScore W2047236475C134018914 @default.
• W2047236475 hasConceptScore W2047236475C16993767 @default.
• W2047236475 hasConceptScore W2047236475C170493617 @default.
• W2047236475 hasConceptScore W2047236475C17991360 @default.
• W2047236475 hasConceptScore W2047236475C185592680 @default.
• W2047236475 hasConceptScore W2047236475C204232928 @default.
• W2047236475 hasConceptScore W2047236475C2775991916 @default.
• W2047236475 hasConceptScore W2047236475C2777107010 @default.
• W2047236475 hasConceptScore W2047236475C2779708716 @default.
• W2047236475 hasConceptScore W2047236475C2780820201 @default.
• W2047236475 hasConceptScore W2047236475C3673659 @default.
• W2047236475 hasConceptScore W2047236475C42219234 @default.
• W2047236475 hasConceptScore W2047236475C55493867 @default.
• W2047236475 hasConceptScore W2047236475C62525196 @default.
• W2047236475 hasConceptScore W2047236475C71924100 @default.
• W2047236475 hasConceptScore W2047236475C90149880 @default.
• W2047236475 hasConceptScore W2047236475C93880895 @default.
• W2047236475 hasConceptScore W2047236475C94412978 @default.
• W2047236475 hasConceptScore W2047236475C98274493 @default.

• next